Results 261 to 270 of about 3,931,468 (303)

Translocation of Proteins into Mitochondria

IUBMB Life, 2001
AbstractThe translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria. Although the import pathway of proteins directed to the mitochondrial matrix has been well characterized, recent studies into the import pathway taken by proteins ...
Hoogenraad, Nicholas Johannes., Ryan, Michael Thomas.   +1 more
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Translocation of Proteins into Mitochondria

Annual Review of Biochemistry, 2007
About 10% to 15% of the nuclear genes of eukaryotic organisms encode mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by receptors on the surface of mitochondria. Translocases in the outer and inner membrane of mitochondria mediate the import and intramitochondrial sorting of these proteins; ATP and the membrane ...
Walter, Neupert, Johannes M, Herrmann
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Protein translocation into mitochondria

BioFactors, 1998
AbstractThe mitochondrial membranes contain translocation machineries (“preprotein translocases”) which facilitate transport of proteins from the cytosol into the mitochondria. The TOM complex is localized in the outer membrane. Two translocases have been characterized in the inner membrane: the Tim23‐Tim17 complex and
K, Káldi, W, Neupert
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Thermodynamics of the Protein Translocation

2009
Many proteins synthesized in bacteria are secreted from the cytoplasm into the periplasm to function in the cell envelope or in the extracellular medium. The Sec translocase is a primary and evolutionary conserved secretion pathway in bacteria. It catalyzes the translocation of unfolded proteins across the cytoplasmic membrane via the pore-forming ...
Kedrov, A., den Blaauwen, T., Driessen, A.J.M.   +2 more
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Protein Translocation Across Membranes

Science, 1988
Many newly synthesized proteins must be translocated across a membrane to reach their final destinations. Translocation requires a signal on the protein itself, a loose conformation of the protein, energy, and receptor-like components in the cytosol and on the target membrane.
Verner K, Schatz G
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Hsp70 proteins in protein translocation

2001
Publisher Summary Hsp70 proteins are essential components of the protein translocation systems of the endoplasmic reticulum (ER) and mitochondria. The role of Hsp70s in protein translocation is not confined to the ER and mitochondria. For most proteins of the ER, translocation is coupled with protein synthesis.
Ryan, Michael T., Pfanner, Nikolaus
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Cellular translocation of proteins by transportan

The FASEB Journal, 2001
ABSTRACT Proteins with molecular masses ranging from 30 kDa (green fluorescent protein, GFP) to 150 kDa (monoclonal and polyclonal antibodies) were coupled to the cellular translocating peptide transportan. We studied the ability of the resulting protein–peptide constructs to penetrate into Bowes melanoma, BRL, and COS‐7 cells.
M, Pooga, C, Kut, M, Kihlmark, M, Hällbrink, S, Fernaeus, R, Raid, T, Land, E, Hallberg, T, Bartfai, U, Langel   +9 more
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Mechanisms of protein translocation into mitochondria

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1999
Mitochondrial biogenesis utilizes a complex proteinaceous machinery for the import of cytosolically synthesized preproteins. At least three large multisubunit protein complexes, one in the outer membrane and two in the inner membrane, have been identified.
Voos, Wolfgang, Martin, Heiko, Krimmer, Thomas, Pfanner, Nikolaus   +3 more
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Translocator protein: pharmacology and steroidogenesis

Biochemical Society Transactions, 2015
The translocator protein (TSPO; 18k Da) is an evolutionarily conserved outer mitochondrial membrane (OMM) protein highly expressed in steroid-synthesizing cells and found to possess a number of physiological and drug-binding partners. Extensive pharmacological, biochemical and cell biological research over the years has led to a model of TSPO ...
Andrew, Midzak, Barry, Zirkin, Vassilios, Papadopoulos   +2 more
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Enzymatic detection of protein translocation

Nature Methods, 2005
Fundamental to eukaryotic cell signaling is the regulation of protein function by directed localization. Detection of these events has been largely qualitative owing to the limitations of existing technologies. Here we describe a method for quantitatively assessing protein translocation using proximity-induced enzyme complementation.
Tom S, Wehrman, Clayton L, Casipit, Nevin M, Gewertz, Helen M, Blau   +3 more
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