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Snapshots of membrane-translocating proteins
Trends in Cell Biology, 1996To learn about the molecular mechanism of protein translocation across the membrane of the endoplasmic reticulum (ER), the environment of nascent chains during the translocation process has been characterized using a variety of crosslinking approaches.
B, Martoglio, B, Dobberstein
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DIVERSITY AND EVOLUTION OF PROTEIN TRANSLOCATION
Annual Review of Microbiology, 2005Cells need to translocate proteins into and across hydrophobic membranes in order to interact with the extracellular environment. Although a subset of proteins are thought to spontaneously insert into lipid bilayers, translocation of most transported proteins requires additional cellular components. Such components catalyze efficient lateral transport
Mechthild, Pohlschröder +4 more
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Translocation of polyampholytes and intrinsically disordered proteins⋆
The European Physical Journal E, 2018Polyampholytes are polymers carrying electrical charges of both signs along their backbone. We consider synthetic polyampholytes with a quenched random charge sequence and intrinsically disordered proteins, which have a well-defined charge sequence and behave like polyampholytes in the denaturated state.
Johner, Albert, Joanny, Jean-François
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The Ins and Outs of Protein Translocation
Science, 1997Cells are tiny manufacturing plants for proteins. To ensure the quality of these products, the cell picks out misfolded and misassembled proteins and destroys them. In his Perspective, Riezman describes recent progress in understanding this quality control process and explains a report presented in this issue by [ Biederer et al .][1], which sheds ...
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Twin-Arginine Protein Translocation
2016Twin-arginine protein translocation systems (Tat) translocate fully folded and co-factor-containing proteins across biological membranes. In this review, we focus on the Tat pathway of Gram-positive bacteria. The minimal Tat pathway is composed of two components, namely a TatA and TatC pair, which are often complemented with additional TatA-like ...
Goosens, Vivianne J. +1 more
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The protein translocation machinery of the endoplasmic reticulum
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1982Abstract The rough endoplasmic reticulum (r.e.r.) has been postulated to possess a single translation-coupled translocation system (in multiple copies) that effects signal sequence-mediated translocation of all secretory and lysosomal proteins and integration of all integral membrane proteins whose port of entry is the rough ...
P, Walter +3 more
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PROTEIN TRANSLOCATION AND TURNOVER IN EUKARYOTIC CELLS
Trends in Biochemical Sciences, 1989Although most eukaryotic proteins are synthesized in the cytoplasm from mRNAs originating in the nucleus, many function in specialized compartments and must be specifically translocated co- or post-translationally. A variety of signals contained within the amino acid sequence guide these processes as well as direct turnover by different proteolytic ...
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A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion
Cell, 2020Xubo Lin, Liang Ge, Xuan Tao
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Common ground for protein translocation: access control for mitochondria and chloroplasts
Nature Reviews Molecular Cell Biology, 2010Enrico Schleiff, Thomas Becker
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Unfoldase-mediated protein translocation through an α-hemolysin nanopore
Nature Biotechnology, 2013Mark Akeson, Jeff Nivala
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