Results 271 to 280 of about 746,971 (308)

Protein Translocation Across Biological Membranes

Science, 2005
Subcellular compartments have unique protein compositions, yet protein synthesis only occurs in the cytosol and in mitochondria and chloroplasts. How do proteins get where they need to go? The first steps are targeting to an organelle and efficient translocation across its limiting membrane.
William, Wickner, Randy, Schekman
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Translocator protein: pharmacology and steroidogenesis

Biochemical Society Transactions, 2015
The translocator protein (TSPO; 18k Da) is an evolutionarily conserved outer mitochondrial membrane (OMM) protein highly expressed in steroid-synthesizing cells and found to possess a number of physiological and drug-binding partners. Extensive pharmacological, biochemical and cell biological research over the years has led to a model of TSPO ...
Andrew, Midzak, Barry, Zirkin, Vassilios, Papadopoulos   +2 more
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Jamming Protein Translocation

Science Signaling, 2009
Antibiotics promote the destruction of a vital protein translocation complex in bacteria.
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The Sec protein-translocation pathway

Trends in Microbiology, 2001
The Sec machinery (or translocase) provides a major pathway of protein translocation from the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts dynamically with the SecYEG integral membrane components to drive the transmembrane movement of newly synthesized preproteins.
H, Mori, K, Ito
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Bacterial Protein Translocation

1988
Protein translocation is a process common to all cells. Both prokaryotes and eukaryotes are divided into distinct compartments, each containing a unique set of proteins important to specific cellular functions. Except for a few mitochondrial and chloroplast proteins, almost all proteins are synthesized in the cytoplasm; therefore many proteins must ...
Elliott Crooke, William Wickner
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Translocation of Proteins into Mitochondria

Annual Review of Biochemistry, 2007
About 10% to 15% of the nuclear genes of eukaryotic organisms encode mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by receptors on the surface of mitochondria. Translocases in the outer and inner membrane of mitochondria mediate the import and intramitochondrial sorting of these proteins; ATP and the membrane ...
Walter, Neupert, Johannes M, Herrmann
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Chloroplast Protein Translocation

2006
The signal hypothesis, first put forth by G. Blobel and B. Dobberstein over 20 years ago, suggested that all proteins had as part of their primary amino acid sequence an amino-terminal region that defined the destination of proteins carrying that signal.
Mireille C. Perret, Karen K. Bernd, Bruce D. Kohorn   +2 more
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Mitochondrial protein translocation-associated degradation

Nature, 2019
Mitochondrial biogenesis and functions depend on the import of precursor proteins via the 'translocase of the outer membrane' (TOM complex). Defects in protein import lead to an accumulation of mitochondrial precursor proteins that induces a range of cellular stress responses.
Mårtensson, Christoph U., Priesnitz, Chantal, Song, Jiyao, Ellenrieder, Lars, Doan, Kim Nguyen, Boos, Felix, Floerchinger, Alessia, Zufall, Nicole, Oeljeklaus, Silke, Warscheid, Bettina, Becker, Thomas   +10 more
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Enzymatic detection of protein translocation

Nature Methods, 2005
Fundamental to eukaryotic cell signaling is the regulation of protein function by directed localization. Detection of these events has been largely qualitative owing to the limitations of existing technologies. Here we describe a method for quantitatively assessing protein translocation using proximity-induced enzyme complementation.
Tom S, Wehrman, Clayton L, Casipit, Nevin M, Gewertz, Helen M, Blau   +3 more
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Translocation of Proteins into Mitochondria

IUBMB Life, 2001
AbstractThe translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria. Although the import pathway of proteins directed to the mitochondrial matrix has been well characterized, recent studies into the import pathway taken by proteins ...
Hoogenraad, Nicholas Johannes., Ryan, Michael Thomas.   +1 more
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