Results 51 to 60 of about 6,532,398 (348)

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
A. Tzagoloff, A. Tzagoloff, A.J. Caplan, A.J. Caplan, B.D. Gambill, B.S. Glick, C.K. Suzuki, D. Ang, D. M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.P. Atencio, E. Ikeda, E. Kutejová, E.A. Craig, E.A. Craig, F.-U. Hartl, G.S.P. Groot, H.R.B. Pelham, J. Ostermann, J. Rassow, J.F. Dice, J.P. Hendrick, K. Liberek, L. Dyck van, M. Eilers, M. Kiebler, M. Schleyer, M.-J. Gething, M.Y. Cheng, N. Rowley, N. Wang, P. Borst, P. Terpstra, P.-J. Kang, R. A. Stuart, R.A. Stuart, R.A. Stuart, R.B. Deshaies, R.G. Hadikusumo, R.J. Nelson, R.P. Beckman, S. Lindquist, S. Rospert, S.T. Hwang, T. Langer, U.C. Manning-Krieg, W. Neupert, W. Neupert, W. Voos, W.J. Chirico, Z. Xia   +53 more
core   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Brown, DA, Filippov, AK, Hughes, S, Marsh, SJ, Tatulian, L, Winks, JS   +6 more
core   +1 more source

Structure-based working model of SecDF, a proton-driven bacterial protein translocation factor

FEMS Microbiology Letters, 2018
The bacterial membrane protein SecDF enhances protein translocation across the membrane driven by the complex of SecA ATPase and SecYEG. Many newly synthesized proteins in the cytoplasm are programmed to be translocated to the periplasm via the narrow ...
T. Tsukazaki
semanticscholar   +1 more source

Regulation of Neuronal Protein Trafficking and Translocation by SUMOylation

Biomolecules, 2012
Post-translational modifications of proteins are essential for cell function. Covalent modification by SUMO (small ubiquitin-like modifier) plays a role in multiple cell processes, including transcriptional regulation, DNA damage repair, protein ...
Jeremy M. Henley, Kevin A. Wilkinson, Anja Berndt   +2 more
doaj   +1 more source

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

eLife, 2020
In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How
Claudia C Schmidt, Vedran Vasic, Alexander Stein   +2 more
doaj   +1 more source

Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents

Cellular and Molecular Life Sciences, 2018
Proteins routed to the secretory pathway start their journey by being transported across biological membranes, such as the endoplasmic reticulum. The essential nature of this protein translocation process has led to the evolution of several factors that ...
Victor Van Puyenbroeck, K. Vermeire
semanticscholar   +1 more source

Insight Into Distinct Functional Roles of the Flagellar ATPase Complex for Flagellar Assembly in Salmonella

Frontiers in Microbiology, 2022
Most motile bacteria utilize the flagellar type III secretion system (fT3SS) to construct the flagellum, which is a supramolecular motility machine consisting of basal body rings and an axial structure.
Tohru Minamino, Miki Kinoshita, Keiichi Namba, Keiichi Namba, Keiichi Namba   +4 more
doaj   +1 more source

Genetic Analysis of Protein Translocation. [PDF]

Protein J, 2019
Cells in all domains of life must translocate newly synthesized proteins both across membranes and into membranes. In eukaryotes, proteins are translocated into the lumen of the ER or the ER membrane. In prokaryotes, proteins are translocated into the cytoplasmic membrane or through the membrane into the periplasm for Gram-negative bacteria or the ...
Silhavy TJ, Mitchell AM.
europepmc   +4 more sources

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J., Ilangovan, Aravindan, Lang, S., Redzej, Adam, Topf, Maya, Waksman, Gabriel, Zangger, K., Zechner, E.L.   +7 more
core   +1 more source

Dynamic action of the Sec machinery during initiation, protein translocation and termination

bioRxiv, 2018
Protein translocation across cell membranes is a ubiquitous process required for protein secretion and membrane protein insertion. This is mediated, for the majority of proteins, by the highly conserved Sec machinery. The bacterial translocon – SecYMKEG –
Tomas Fessl, Daniel W. Watkins, Peter Oatley, W. Allen, R. Corey, Jim E. Horne, S. Baldwin, S. Radford, I. Collinson, R. Tuma   +9 more
semanticscholar   +1 more source