Results 21 to 30 of about 56,365 (241)
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
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Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant [PDF]
, 2016 In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants.
Braeckman, Bart +4 more
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Proteostasis and ageing: insights from long-lived mutant mice [PDF]
, 2017 The global increase in life expectancy is creating significant medical, social and economic challenges to current and future generations. Consequently, there is a need to identify the fundamental mechanisms underlying the ageing process.
Page, Melissa M. +2 more
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PLoS Biology, 2022 The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes.
Jimin Yoon +12 more
doaj +1 more source
Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. [PDF]
, 2018 Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role
Armstrong, Cameron M +12 more
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Cell Reports, 2013 The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6.
Matthew D. Shoulders +9 more
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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. [PDF]
, 2020 Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown.
Chua, Bernadette A +7 more
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Prion degradation pathways: Potential for therapeutic intervention [PDF]
, 2015 Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
Goold, R, McKinnon, C, Tabrizi, SJ
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Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
doaj +1 more source
Editorial: Yeast cell aging and death [PDF]
, 2018 A conspicuous amount of knowledge about the molecular biol- ogy of the cell has come from studies on yeast Saccharomyces cere- visiae, mostly because of its unrivaled qualities as a toolkit for molecular genetics study.
Cristina Mazzoni, Sergio Giannattasio
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