Results 21 to 30 of about 62,588 (334)
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Cells, 2020 Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins ...
Tuuli-Maria Sonninen +4 more
doaj +1 more source
Adapting Proteostasis for Disease Intervention
Science, 2008 The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the
W. Balch +3 more
semanticscholar +3 more sources
Cell Death and Disease, 2023 Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators.
Jian Cheng +10 more
doaj +1 more source
Secretory autophagy maintains proteostasis upon lysosome inhibition
Journal of Cell Biology, 2022 Solvik et al. reveal that the autophagy machinery facilitates the secretion of autophagy cargo receptors and other cellular components via extracellular vesicles and particles in response to lysosome inhibition or impaired autophagosome maturation.
T. Solvik +7 more
semanticscholar +1 more source
A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
Cell Reports, 2014 Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and ...
Marc Brehme +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins +2 more
doaj +1 more source
Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
doaj +1 more source
Insights Into the Links Between Proteostasis and Aging From C. elegans
Frontiers in Aging, 2022 Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to ensure
William Hongyu Zhang +4 more
doaj +1 more source
Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]
, 2017 Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio +1 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
doaj +1 more source