Results 41 to 50 of about 62,588 (334)

Proteostasis and ageing: insights from long-lived mutant mice [PDF]

, 2017
The global increase in life expectancy is creating significant medical, social and economic challenges to current and future generations. Consequently, there is a need to identify the fundamental mechanisms underlying the ageing process.
Page, Melissa M., Sands, William A., Selman, Colin   +2 more
core   +1 more source

Pathways of cellular proteostasis in aging and disease

Journal of Cell Biology, 2018
Klaips et al. outline the pathways and molecular mechanisms of cellular protein homeostasis, or proteostasis, and discuss how a decline in proteostasis during aging contributes to disease.
C. L. Klaips, G. Jayaraj, F. Hartl
semanticscholar   +1 more source

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis

Science, 2021
Transcriptional control of proteostasis Tissue homeostasis requires the coordinated activity of multiple cell types to initiate and then resolve inflammation.
Kwontae You, Lingfei Wang, Chih-Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, J. Yao, A. Lefkovith, Abdifatah S Omar, J. Perrigoue, J. Towne, A. Regev, D. Graham, R. Xavier   +13 more
semanticscholar   +1 more source

Synaptic proteostasis in Parkinson's disease

Current Opinion in Neurobiology, 2022
There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death.
Nachman, Eliana, Verstreken, Patrik
openaire   +2 more sources

Maintaining proteostasis under mechanical stress [PDF]

EMBO reports, 2021
Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or ...
Jörg Höhfeld, Thomas Benzing, Wilhelm Bloch, Dieter O Fürst, Sebastian Gehlert, Michael Hesse, Bernd Hoffmann, Thorsten Hoppe, Pitter F Huesgen, Maja Köhn, Waldemar Kolanus, Rudolf Merkel, Carien M Niessen, Wojciech Pokrzywa, Markus M Rinschen, Dagmar Wachten, Bettina Warscheid   +16 more
openaire   +5 more sources

Editorial: Yeast cell aging and death [PDF]

, 2018
A conspicuous amount of knowledge about the molecular biol- ogy of the cell has come from studies on yeast Saccharomyces cere- visiae, mostly because of its unrivaled qualities as a toolkit for molecular genetics study.
Cristina Mazzoni, Sergio Giannattasio
core   +1 more source

Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

Frontiers in Cell and Developmental Biology, 2023
The disturbance in mitochondrial functions and homeostasis are the major features of neuron degenerative conditions, like Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Alzheimer’s disease, along with protein misfolding.
Y. A. Jagtap, Prashant Kumar, Sumit Kinger, A. R. Dubey, Akash Choudhary, R. Gutti, Sarika Singh, H. Jha, K. Poluri, A. Mishra   +9 more
semanticscholar   +1 more source

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope.

PLoS Biology, 2022
The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes.
Jimin Yoon, Emmanuel E Nekongo, Jessica E Patrick, Tiffani Hui, Angela M Phillips, Anna I Ponomarenko, Samuel J Hendel, Rebecca M Sebastian, Yu Meng Zhang, Vincent L Butty, C Brandon Ogbunugafor, Yu-Shan Lin, Matthew D Shoulders   +12 more
doaj   +1 more source

Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. [PDF]

, 2018
Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role
Armstrong, Cameron M, Chen, Hong-Wu, Dall'Era, Marc, Evans, Christopher P, Gao, Allen C, Liu, Chengfei, Liu, Liangren, Lombard, Alan P, Lou, Wei, Noel, Onika DV, Tepper, Clifford G, Yang, Joy C, Zhao, Ruining   +12 more
core   +2 more sources

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis in Alzheimer’s disease models

bioRxiv, 2023
Alzheimer’s Disease (AD) is a progressive and irreversible neurodegenerative disorder, characterized by the accumulation of abeta-amyloid aggregates, which triggers tau hyperphosphorylation and neuronal loss.
Marisa Pereira, D. R. Ribeiro, Maximilian Berg, A. Tsai, K. Nho, Stefanie Kaiser, Miguel Moutinho, A. Soares   +7 more
semanticscholar   +1 more source