Results 91 to 100 of about 5,276 (193)

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies [PDF]

, 2017
BACKGROUND: Mutations in the gene encoding thymidine kinase 2 (TK2) result in the myopathic form of mitochondrial DNA depletion syndrome which is a mitochondrial encephalomyopathy presenting in children. In order to unveil some of the mechanisms involved
Artuch Iriberri, Rafael, Colomer Oferil, Jaume, De Meirleir, Linda, De Paepe, Boel, Fagiolari, Gigliola, Ferrer, Isidro (Ferrer Abizanda), Jekovec-Vrhovsek, Maja, Jiménez Mallebrera, Cecilia, Jou, Cristina, Kalko, Susana, López Gallardo, Ester, Meznaric, Marija, Moggio, Maurizio, Montero Sánchez, Raquel, Montoya, Julio, Munell Casadesús, Francina, Nascimento, Andrés, Ortez, Carlos Ignacio, Paco Mercader, Sonia, Rodríguez, María Angeles, Rogac, Mihael, Roig Quilis, Manuel, Ruiz Pesini, Eduardo, Sciacco, Monica, Torner Rubies, Ferran   +24 more
core   +1 more source

MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1

Cellular Physiology and Biochemistry, 2015
Background/Aims: Emerging evidence indicates that microRNA (miR)-340 is downregulated in various human cancers, suggesting that it acts as a tumor suppressor.
Shuo Yan, Haosheng Jiang, Shiming Fang, Fang Yin, Zhenlei Wang, Yiping Jia, Xianjun Sun, Shaoqiu Wu, Tinghui Jiang, Aiwu Mao   +9 more
doaj   +1 more source

Role of Glutamine Metabolism in Stomach Adenocarcinoma Progression, Prognosis, and Immunity

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background The specific role of glutamine metabolism in stomach adenocarcinoma (STAD) remains incompletely understood. Methods To examine the involvement of glutamine metabolism in STAD, we used R software to perform clustering and prognostic analyses based on glutamine metabolism‐related genes (GMGs).
Han Ge, Peng Xu, Chen Chen, Kanghui Liu, Jialun Lv, Shansong Huang, Peicheng Ji, Qingya Li, Linjun Wang, Hao Xu, Li Yang, Diancai Zhang, Zekuan Xu, Suraiya Saleem   +13 more
wiley   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

Y‐Box‐Binding Protein 1 Facilitates the Proliferation and Osteogenic Differentiation of Periodontal Ligament Stem Cells Through the Transcriptional Activation of FGF2‐Mediated Akt/GSK3β/β‐Catenin Signaling

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.
ABSTRACT Periodontal ligament stem cells (PDLSCs) are derived from periodontal tissue and can differentiate into osteoblasts, which are ideal materials for alveolar bone repair and periodontal tissue regeneration. In this study, we aimed to explore the effects of Y‐box binding protein 1 (YB‐1) on the osteogenic differentiation and proliferation of ...
Yun‐Hao Xi, Chang‐Shun Li, Pin‐Lin Wu, Xiao‐Yang Zhou, Qian‐Wen Li, Cheng‐Hui Shen   +5 more
wiley   +1 more source

Hydrocortisone interacts with endoplasmic reticulum stress in hypoxic regulation of phosphoserine aminotransferase 1 gene expression differently in normal human astrocytes and glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum (ER) stress and hypoxia are key factors for the effective growth of malignant tumors, including glioblastoma. The phosphoserine aminotransferase 1 (PSAT1) is an ER stress-responsive enzyme responsible for serine synthesis
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khikhlo Yevgen P., Sliusar Myroslava Y., Halkin Oleh V., Luzina Olha Y., Danilovsryi Serhiy V., Viletska Yuliia M., Minchenko Dmytro O.   +8 more
doaj   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

MedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao, Yuan Gao, Xiaolong Yan   +11 more
wiley   +1 more source

Proyecto de rehabilitación de una casa rural entre medianeras en la Ginebrosa (Teruel) [PDF]

, 2013
This project consists of four parts. The first part is the building diagnosis, in which the current strength of the structure has been valued and this was compared with the resistance that should have according to safety requirements indicated in the ...
Lozano Bernuz, Raquel
core