Results 121 to 130 of about 5,276 (193)

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. [PDF]

, 2019
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood.
Amaravadi, Ravi K, Chinga, Frank, Conn, Crystal S, Diehl, J Alan, Fu, Weixuan, Fuchs, Serge Y, Ignatova, Zoya, Kossenkov, Andrew, Koumenis, Constantinos, Leli, Nektaria Maria, Monroy, Alexandra M, Ojha, Rani, Polte, Christine, Ruggero, Davide, Salas Salinas, Carlo, Tameire, Feven, Verginadis, Ioannis I, Wang, Paul, Ye, Jiangbin   +18 more
core  

Additional file 6 of PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Additional file 6: Table S3. Differentially expressed genes in PDLSCs that have co-expression relationships with PSAT1.
Jia, Linglu, Li, Dongfang, Wang, Ya-Nan, Zhang, Dongjiao, Xu, Xin   +4 more
openaire   +1 more source

Additional file 2 of PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Additional file 2: Table S2. The sequences of primers utilized for qRT-PCR.
Jia, Linglu, Li, Dongfang, Wang, Ya-Nan, Zhang, Dongjiao, Xu, Xin   +4 more
openaire   +1 more source

Additional file 5 of PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Additional file 5: Figure S2. The interference efficiency of using siRNA to interfere with target genes in PDLSCs.
Jia, Linglu, Li, Dongfang, Wang, Ya-Nan, Zhang, Dongjiao, Xu, Xin   +4 more
openaire   +1 more source

PSAT1 Gene [PDF]

, 2020
openaire   +1 more source

PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma

Autophagy
The mechanistic target of rapamycin complex 1 (mTORC1) integrates environmental cues, especially amino acids, to regulate metabolism and ultimately cancer progression. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis and its overexpression has been reported to promote oncogenesis in various cancers.
Liu, Yuhan, Cheng, Zhujun, Zhang, Jinjin, Zhang, Yi, Zhao, Tao, Sun, Longhua, Wen, Guilan, Han, Tianyu, Wang, Jianbin   +8 more
openaire   +1 more source

PSAT1 wt Allele [PDF]

, 2020
openaire   +1 more source

Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression. [PDF]

, 2019
This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Metcalf, Stephanie
core   +1 more source

Phosphoserine aminotransferase 1 (PSAT1) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

AbstractSerine metabolism is of growing biologic and therapeutic interest in cancer. Upregulation of the serine synthesis pathway (SSP) can fuel tumor growth, and cancers with this phenotype are often sensitive to SSP inhibitors. In parallel, dietary restriction of serine and glycine (SG) can suppress some cancers, but the determinants of sensitivity ...
Ilias Sinanidis, Panagiotis Tsakiroglou, Benjamin Dubner, Rebecca Foertsch, Julia Gondek, InYoung Choi, Bogdan Paun, Liang Zhao, Gabriel Ghiaur, W. Brian Dalton   +9 more
openaire   +1 more source