Results 241 to 250 of about 1,773,773 (285)

Assessing pulmonary vascular remodeling in connective tissue disease-associated interstitial lung disease: a CT-based quantitative analysis. [PDF]

Quant Imaging Med Surg
Li R, Liu S, Wang X, Wang R, E L.
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Intravenous mesenchymal stem cell transplantation mitigates pulmonary vascular remodeling but poses dose related risks in a pulmonary veno-occlusive disease model. [PDF]

Stem Cell Res Ther
Katagiri J, Homma J, Takagi R, Sekine H, Shinkawa T, Niinami H, Shimizu T.   +6 more
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Quercetin regulates pulmonary vascular remodeling in pulmonary hypertension by downregulating TGF-β1-Smad2/3 pathway. [PDF]

BMC Cardiovasc Disord
Gao RJ, Aikeremu N, Cao N, Chen C, Ma KT, Li L, Zhang AM, Si JQ.   +7 more
europepmc   +1 more source

Pulmonary Vascular Remodeling in Pulmonary Hypertension

Journal of Personalized Medicine, 2023
Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle ...
Xian-Liang Wang, Shan-Shan Lin, Zhuangzhuang Jia   +2 more
exaly   +4 more sources

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension [PDF]

Trends in Molecular Medicine, 2017
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death ...
Allan Lawrie, A A Roger Thompson, A A Roger Thompson   +2 more
exaly   +2 more sources

Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary Hypertension [PDF]

B56. LET'S GET PHYSICAL: EXERCISE AND BIOMECHANICS OF PAH, 2019
Exercise stress testing of the pulmonary circulation may uncover decreased pulmonary vascular (PV) distensibility as a cause of impaired aerobic exercise capacity and right ventricular (RV)-pulmonary arterial (PA) uncoupling. As such, it may help in the differential diagnosis of unexplained dyspnea, including pulmonary hypertension (PH) and/or heart ...
Singh, Inderjit, Oliveira, Rudolf R.K.F., Naeije, Robert, Rahaghi, Farbod Nicholas, Oldham, William W.M., Systrom, David D.M., Waxman, Aaron A.B.   +6 more
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CFTR in the regulation of pulmonary vascular tone and remodeling

European Respiratory Journal, 2021
We read with great interest the recently published article by Helene Le Ribeuz and colleagues on the role of CFTR in the pathogenesis of pulmonary arterial hypertension (PAH) in the European Respiratory Journal [1]. In this work, the authors propose that loss of cystic fibrosis transmembrane conductance regulator (CFTR) drives increased pulmonary ...
Christoph, Tabeling, Martin, Witzenrath, Wolfgang M, Kuebler   +2 more
openaire   +2 more sources

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

Journal of the American College of Cardiology, 2009
Inflammatory processes are prominent in various types of human and experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic components of pulmonary vascular remodeling. Macrophages, T and B lymphocytes, and dendritic cells are present in the vascular lesions of PH, whether in idiopathic pulmonary arterial ...
Nicholas W Morrell, Kurt R Stenmark, Marlene Rabinovitch   +2 more
exaly   +3 more sources

Levosimendan attenuates pulmonary vascular remodeling

Intensive Care Medicine, 2011
The calcium-sensitizing drug levosimendan increases myocardial contractility and, by activating K(+)-channels, dilates pulmonary vessels. In the acute setting, levosimendan is clinically used to treat right heart failure in pulmonary hypertension. As K(+)-channel activation elicits several beneficial effects in the vascular system, we hypothesized that
M, Revermann, M, Schloss, A, Mieth, A, Babelova, K, Schröder, S, Neofitidou, J, Buerkl, T, Kirschning, R T, Schermuly, C, Hofstetter, R P, Brandes   +10 more
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Role of the Adventitia in Pulmonary Vascular Remodeling

Physiology, 2006
An increasing volume of experimental data indicates that the adventitial fibroblast, in both the pulmonary and systemic circulations, is a critical regulator of vascular wall function in health and disease. A rapidly emerging concept is that the vascular adventitia acts as biological processing center for the retrieval, integration, storage, and ...
Kurt R, Stenmark, Neil, Davie, Maria, Frid, Evgenia, Gerasimovskaya, Mita, Das   +4 more
openaire   +2 more sources