Results 251 to 260 of about 1,773,773 (285)
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The role of mitochondria in pulmonary vascular remodeling
Journal of Molecular Medicine, 2010Pulmonary arterial hypertension (PAH) is characterized by a hyperproliferative and anti-apoptotic diathesis within the vascular wall of the resistance pulmonary arteries, leading to vascular lumen occlusion, right ventricular failure, and death. Most current therapies show poor efficacy due to emphasis on vasodilation (rather than proliferation ...
Peter, Dromparis +2 more
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Seminars in Pediatric Surgery, 2007
The maladaptive response of the pulmonary vasculature that occurs in patients with congenital diaphragmatic hernia significantly impacts outcome. Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertension.
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The maladaptive response of the pulmonary vasculature that occurs in patients with congenital diaphragmatic hernia significantly impacts outcome. Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertension.
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Progression of vascular remodeling in pulmonary vein obstruction
The Journal of Thoracic and Cardiovascular Surgery, 2020Pulmonary vein obstruction (PVO) frequently occurs after repair of total anomalous pulmonary vein connection with progression of intimal hyperplasia from the anastomotic site toward upstream pulmonary veins (PVs). However, the understanding of mechanism in PVO progression is constrained by lack of data derived from a physiological model of the disease,
Naoki, Masaki +6 more
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Adverse Pulmonary Vascular Remodeling in the Fontan Circulation
Journal of Heart and Lung Transplantation, 2015The Fontan circulation is a palliation for patients with a functionally univentricular heart. It is characterized by gradual attrition over time. An increase in pulmonary vascular resistance could be a key factor in the long-term failure of the Fontan circulation.
Floris-Jan S Ridderbos +2 more
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Activation of PKCα and pulmonary vascular remodelling in broilers
Research in Veterinary Science, 2005The present study was conducted to examine the presence of protein kinase Calpha (PKCalpha) in the pulmonary arterioles of broilers during the development of pulmonary hypertension and pulmonary vascular remodelling.One hundred and sixty day-old Avian-2000 broilers were divided equally into a control group and a cold temperature group.
Xun, Tan +5 more
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Hypertension, 2011 We have found that 15-hydroxyeicosatetraenoic acid (15-HETE) induced by hypoxia was an important mediator in the regulation of hypoxic pulmonary hypertension, including the pulmonary vasoconstriction and remodeling.
Zhenwei Pan, Qian Li, Yaqian Li
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Pulmonary hypertension and vascular remodeling in fetal sheep
American Journal of Physiology-Heart and Circulatory Physiology, 1994Vascular remodeling is commonly associated with pulmonary hypertension (PH) postnatally, but little is known about its presence in fetuses. In sixteen fetal sheep (126 wk gestation), the ductus arteriosus (DA) was ligated, and the animals were studied at 4, 8, and 14 days after surgery. The uninstrumented twins served as controls.
J, Belik +3 more
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CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELING
Annual Review of Physiology, 1997▪ Abstract In many organs and tissues, the cellular response to injury is associated with a reiteration of specific developmental processes. Studies have shown that, in response to injury, vascular wall cells in adult organisms express genes or gene products characteristic of earlier developmental states. Other genes, expressed preferentially in adult
K R, Stenmark, R P, Mecham
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The Adventitia: Essential Role in Pulmonary Vascular Remodeling
Comprehensive Physiology, 2011Abstract A rapidly emerging concept is that the vascular adventitia acts as a biological processing center for the retrieval, integration, storage, and release of key regulators of vessel wall function. It is the most complex compartment of the vessel wall and comprises a variety of cells including fibroblasts ...
Kurt R, Stenmark +6 more
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Osteopontin May Be Responsible for Pulmonary Vascular Remodeling
Chest, 20052005;128;621S Chest Toshiharu Tabata, Yuji Matsumura and Takashi Kondo Yasushi Hoshikawa, Yasushi Matsuda, Satoshi Suzuki, Yoshinori Okada, * Pulmonary Vascular Remodeling Osteopontin May Be Responsible for http://chestjournal.chestpubs.org/content/128/6_suppl/621S.1.full.html services can be found online on the World Wide Web at: The online version of
Yasushi, Hoshikawa +6 more
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