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Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension
Progress in Cardiovascular Diseases, 2002Clinical pulmonary hypertension is characterized by a sustained elevation in pulmonary arterial pressure. Pulmonary vascular remodeling involves structural changes in the normal architecture of the walls of pulmonary arteries. The process of vascular remodeling can occur as a primary response to injury, or stimulus such as hypoxia, within the ...
T K, Jeffery, N W, Morrell
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MMP8-mediated vascular remodeling in pulmonary hypertension
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseasePulmonary arterial hypertension (PAH) is a vascular remodeling disease that impacts the cardiopulmonary system. Due to the currently limited understanding of vascular remodeling, a cure for PAH remains elusive. This study highlights the critical role of the STAT1 (signal transducer and activator of transcription 1)/MMP8 (matrix metallopeptidase 8)/DRP1
Xiaodong, Deng +3 more
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Pulmonary Vascular Remodeling in Pulmonary Hypertension Mice Aggravated by Hypothyroidism
EndocrinologyAbstract Objective This study aimed to investigate the impact of hypothyroidism on pulmonary vascular remodeling (PVR) in pulmonary hypertension (PH) mice and the therapeutic effects of levothyroxine (L-T4). Methods Male C57BL/6J mice
Hongling Zhang +3 more
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