Results 161 to 170 of about 45,726 (286)

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Extracellular purines in lung endothelial permeability and pulmonary diseases

Frontiers in Physiology
The purinergic signaling system is an evolutionarily conserved and critical regulatory circuit that maintains homeostatic balance across various organ systems and cell types by providing compensatory responses to diverse pathologies.
Evgenia Gerasimovskaya, Rahul S. Patil, Adrian Davies, McKenzie E. Maloney, McKenzie E. Maloney, Liselle Simon, Basmah Mohamed, Mary Cherian-Shaw, Alexander D. Verin, Alexander D. Verin   +9 more
doaj   +1 more source

Physiological characterization of purinergic signaling in single spermatogonia in vitro and in situ

, 2016
David Fleck
openalex   +2 more sources

The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
The interplay between ferroptosis and the tumor immune microenvironment significantly influences the outcome of cancer immunotherapy. Inducing ferroptosis in tumor cells and immunosuppressive cells, while preventing ferroptosis in effector immune cells, emerges as a promising strategy to enhance the efficacy of immunotherapy. This review highlights the
Fenfen Zhan, Yanyan Hu, Xiang Jiang, Zejun Fang   +3 more
wiley   +1 more source

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels [PDF]

, 2020
Sean McCutcheon, Robert J. Majeska, David C. Spray, Mitchell B. Schaffler, Maribel Vázquez   +4 more
openalex   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss, Christine Heuer, Marina Herwerth   +2 more
doaj   +1 more source

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana, Schäfer, Liliana, Young, Marian F.   +2 more
core  

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, Volume 183, Issue 1, Page 40-56, January 2026.
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

Editorial: Purinergic Signaling and Inflammation [PDF]

Frontiers in Immunology, 2021
Xiaoyi Yuan, Davide Ferrari, Tingting Mills, Yanyu Wang, Agnieszka Czopik, Marie-Francoise Doursout, Scott E. Evans, Marco Idzko, Holger K. Eltzschig   +8 more
openaire   +3 more sources