Results 31 to 40 of about 4,625,876 (321)

Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation

Frontiers in Immunology, 2022
CD39/NTPDase1 has emerged as an important molecule that contributes to maintain inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible role of CD39 in COVID-19 pathophysiology since no confirmatory data shed light in ...
E. Díaz-García, S. García-Tovar, Enrique Alfaro, Ester Zamarrón, A. Mangas, R. Galera, J. Ruiz-Hernandez, J. Solé-Violán, C. Rodríguez-Gallego, Ana van-den-Rym, R. Pérez-de-Diego, K. Nanwani-Nanwani, E. López-Collazo, F. García-Río, C. Cubillos-Zapata   +14 more
semanticscholar   +1 more source

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively

Frontiers in Pharmacology, 2022
There is ongoing dispute on the question whether CNS neurons possess ATP-sensitive P2X7 receptors (Rs) or whether only non-neuronal cells bear this receptor-type and indirectly signal to the neighboring neurons. We genetically deleted P2X7Rs specifically
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Patrizia Rubini, Peter Illes, Peter Illes, Peter Illes, Yong Tang, Yong Tang, Yong Tang   +9 more
doaj   +1 more source

P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases

eNeuro, 2022
Visual Abstract Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on energy supply, nerve cells are especially vulnerable to impaired ...
A. S. Zelentsova, A. Deykin, V. Soldatov, A. A. Ulezko, Alina Y Borisova, V. S. Belyaeva, M. Skorkina, Plamena R. Angelova   +7 more
semanticscholar   +1 more source

Purinergic signalling in bone [PDF]

Frontiers in Endocrinology, 2012
Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells. Since then the expression of nearly all the P2Y and P2X receptors by osteoblasts and osteoclasts has been reported, mediating multiple processes including cell ...
Rumney, Robin M.H., Wang, Ning, Agrawal, Ankita, Gartland, Alison   +3 more
openaire   +5 more sources

P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis

Frontiers in Immunology, 2021
Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang   +7 more
doaj   +1 more source

Purinergic signaling in scarring [PDF]

The FASEB Journal, 2015
Adenosine (ADO) and nucleotides such as ATP, ADP, and uridine 5'-triphosphate (UTP), among others, may serve as extracellular signaling molecules. These mediators activate specific cell-surface receptors-namely, purinergic 1 and 2 (P1 and P2)-to modulate crucial pathophysiological responses.
FERRARI, Davide, GAMBARI, Roberto, Idzko, Marco, Müller, Tobias, Albanesi, Cristina, Pastore, Saveria, La Manna, Gaetano, Robson, Simon C, Cronstein, Bruce   +8 more
openaire   +5 more sources

Purinergic signalling and diabetes [PDF]

Purinergic Signalling, 2013
The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the balance is broken-cells can be starving in the midst of plenty. There are indications that the incidence of diabetes type 1 and 2, and possibly pancreatogenic diabetes, is ...
Burnstock, G, Novak, I
openaire   +4 more sources

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration

Frontiers in Neuroscience, 2023
Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak, Kailun Jiang, Christopher J. Campbell, Joanne A. Matsubara   +3 more
doaj   +1 more source

Delineating Purinergic Signaling in Drosophila. [PDF]

Int J Mol Sci, 2022
Simplistic models can aid in discovering what is important in the context of normal and pathological behavior. First recognized as a genetic model more than 100 years ago, to date, fruit flies (Drosophila melanogaster) still remain an astonishingly good laboratory stand-in for scientists to study development and physiology and to investigate the ...
Volonté C, Alberti F, Vitale G, Liguori F.   +3 more
europepmc   +3 more sources