The role of purinergic signaling in microglial responses
Stress and Brain, 2021 Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes.
Yaling Hu, Zhihua Gao
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Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]
, 2013 Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C. +4 more
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Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
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The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
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Emerging roles of purinergic signaling in anti-cancer therapy resistance
Frontiers in Cell and Developmental Biology, 2022 Cancer is a complex disease with a rapid growing incidence and often characterized by a poor prognosis. Although impressive advances have been made in cancer treatments, resistance to therapy remains a critical obstacle for the improvement of patients ...
Michele Zanoni +3 more
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P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]
, 2008 ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank +6 more
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Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]
, 2019 Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
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Journal of Pharmaceutical Analysis, 2023 Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen +8 more
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ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Fadi AlDehni +6 more
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P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King +29 more
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