From purines to purinergic signalling: molecular functions and human diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.
Alexei Verkhratsky +2 more
exaly +4 more sources
Therapeutic Potential of Astrocyte Purinergic Signalling in Epilepsy and Multiple Sclerosis [PDF]
Frontiers in Pharmacology, 2022 Epilepsy and multiple sclerosis (MS), two of the most common neurological diseases, are characterized by the establishment of inflammatory environment in the central nervous system that drives disease progression and impacts on neurodegeneration. Current
Paola Nobili +5 more
doaj +3 more sources
Purinergic Signalling: Therapeutic Developments [PDF]
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj +3 more sources
Purinergic Signalling in the Cochlea. [PDF]
Int J Mol Sci, 2022 The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous ...
Vlajkovic SM, Thorne PR.
europepmc +2 more sources
Purinergic signalling in neuroregeneration
Neural Regeneration Research, 2015 Purinergic signalling, adenosine 5′-triphosphate (ATP) as an extracellular signalling molecule, was proposed in 1972 (Burnstock, 1972). However, it was not generally accepted until the early 1990s when receptors for ATP and its breakdown product ...
Geoffrey Burnstock
doaj +3 more sources
Colorectal Cancer and Purinergic Signalling: An Overview. [PDF]
Cancers (Basel), 2022 Highlights What are the main findings? CD39-CD73 axis in tumor-associated immune cells promotes immune exhaustion, impairment of antitumor immune activity, and increased CRC progression. CD73 overexpression in cancer cells is associated with tumor growth,
Roliano GG +5 more
europepmc +2 more sources
Exploration of the link between gut microbiota and purinergic signalling. [PDF]
Purinergic Signal, 2023 Growing evidence reveals that microorganisms in the gut are linked to metabolic health and disease risk in human beings to a considerable extent. The focus of research at this stage must tend to focus on cause-and-effect studies.
Li M +5 more
europepmc +2 more sources
MicroRNA: Crucial modulator in purinergic signalling involved diseases. [PDF]
Purinergic Signal, 2023 Both microRNAs (miRNAs) and purinergic signalling are widely and respectively expressed in various tissues of different organisms and play vital roles in a variety of physiological and pathological processes.
Guo J +6 more
europepmc +2 more sources
Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts [PDF]
Frontiers in Endocrinology, 2023 Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che +9 more
doaj +2 more sources
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling. [PDF]
Purinergic Signal, 2022 Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm.
Hasan D +5 more
europepmc +2 more sources