Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts [PDF]
Frontiers in Endocrinology, 2023 Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che +9 more
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Purinergic Signalling and Inflammation-Related Diseases [PDF]
Cells, 2022 While acute inflammation is widely accepted as an important response mechanism of cells against tissue injury, sustained inflammatory processes are increasingly recognized as one of the main contributors to numerous diseases, including central-nervous ...
Tobias Engel +2 more
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From purines to purinergic signalling: molecular functions and human diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.
Zhao Huang +10 more
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Editorial: Purinergic signalling in the central nervous system and its pharmacological importance in neurological and psychiatric illnesses [PDF]
Frontiers in Pharmacology, 2023 Yong Tang +5 more
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Therapeutic Potential of Astrocyte Purinergic Signalling in Epilepsy and Multiple Sclerosis [PDF]
Frontiers in Pharmacology, 2022 Epilepsy and multiple sclerosis (MS), two of the most common neurological diseases, are characterized by the establishment of inflammatory environment in the central nervous system that drives disease progression and impacts on neurodegeneration. Current
Paola Nobili +5 more
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Purinergic Signalling: Therapeutic Developments [PDF]
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
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Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus? [PDF]
Biomedical Journal, 2016 Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell ...
Francesco Di Virgilio +1 more
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Purinergic Signalling in Group A Streptococcus Pathogenesis [PDF]
Frontiers in Immunology, 2022 T. B-D McEwan +5 more
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Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management [PDF]
Arrhythmia & Electrophysiology Review, 2020 Gareth DK Matthews, Andrew A Grace
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Frontiers in Neuroscience, 2021 One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the ...
Adnan Hassan Tahir +5 more
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