Results 1 to 10 of about 162,902 (284)
From purines to purinergic signalling: molecular functions and human diseases
Signal Transduction and Targeted Therapy, 2021 Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.
Alexei Verkhratsky +2 more
exaly +2 more sources
Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in
Malaria Journal, 2012 Background Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. Methods Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and
Cruz Laura +6 more
doaj +6 more sources
Purinergic signalling: past, present and future [PDF]
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock
doaj +2 more sources
Purinergic regulation of the immune system [PDF]
Nature Reviews Immunology, 2016 Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling molecules by activating cell-surface P2 purinergic receptors that ...
Caglar Cekic, Joel Linden
exaly +3 more sources
Purinergic signalling in neuron–glia interactions [PDF]
Nature Reviews Neuroscience, 2006 R Douglas Fields, Geoffrey Burnstock
exaly +4 more sources
Frontiers in Neuroscience, 2021 One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the ...
Adnan Hassan Tahir +5 more
doaj +1 more source
Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy
Frontiers in Pharmacology, 2023 Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy.
Nan-Rui Shi +16 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che +9 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world.
Jie Li +8 more
doaj +1 more source
Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
Frontiers in Pharmacology, 2021 The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso +8 more
doaj +1 more source