Results 11 to 20 of about 7,662 (216)
Purinergic signalling in neuroregeneration
Neural Regeneration Research, 2015 Purinergic signalling, adenosine 5′-triphosphate (ATP) as an extracellular signalling molecule, was proposed in 1972 (Burnstock, 1972). However, it was not generally accepted until the early 1990s when receptors for ATP and its breakdown product adenosine were cloned and characterised (Ralevic and Burnstock, 1998).
Geoffrey Burnstock
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Purinergic Signalling: Pathophysiological Roles
Japanese Journal of Pharmacology, 1998 In this review, after a summary of the history and current status of the receptors involved in purinergic signalling, we focus on the distribution and physiological roles of purines and pyrimidines in both short-term events such as neurotransmission, exocrine and endocrine secretion and regulation of immune cell function, and long-term events such as ...
Maria P. Abbracchio, Geoffrey Burnstock
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Purinergic Signalling in the Cochlea. [PDF]
Int J Mol Sci, 2022 The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues.
Vlajkovic SM, Thorne PR.
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Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management [PDF]
Arrhythmia & Electrophysiology Review, 2020 Gareth DK Matthews, Andrew A Grace
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Purinergic Signaling in Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 ATP is stored in millimolar concentrations within the intracellular medium but may be released to extracellular sites either through the damaged plasma membrane or by means of various transporters [...]
Dmitry Aminin, Peter Illes
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Frontiers in Neuroscience, 2021 One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the ...
Adnan Hassan Tahir +5 more
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Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy
Frontiers in Pharmacology, 2023 Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy.
Nan-Rui Shi +16 more
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Frontiers in Pharmacology, 2021 Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world.
Jie Li +8 more
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Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
Frontiers in Pharmacology, 2021 The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso +8 more
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Signal Transduction and Targeted Therapy, 2023 Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can ...
Alexei Verkhratsky +7 more
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