Results 21 to 30 of about 7,462 (180)

Purinergic signalling pathway: therapeutic target in ovarian cancer

Egyptian Journal of Medical Human Genetics, 2020
Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers.
Nisha Chandran, Mahalaxmi Iyer, Zothan Siama, Balachandar Vellingiri, Arul Narayanasamy   +4 more
doaj   +1 more source

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +1 more source

Evolutionary origins of taste buds: phylogenetic analysis of purinergic neurotransmission in epithelial chemosensors [PDF]

Open Biology, 2013
Taste buds are gustatory endorgans which use an uncommon purinergic signalling system to transmit information to afferent gustatory nerve fibres. In mammals, ATP is a crucial neurotransmitter released by the taste cells to activate the afferent nerve ...
Masato Kirino, Jason Parnes, Anne Hansen, Sadao Kiyohara, Thomas E. Finger   +4 more
doaj   +1 more source

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

Frontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall, Dan C Gagui, Victoria L Tippett, Norain B Ab Latif, Karan M Shah, Alison Gartland   +5 more
doaj   +1 more source

ATP and Adenosine in the Retina and Retinal Diseases

Frontiers in Pharmacology, 2021
Extracellular ATP and its ultimate degradation product adenosine are potent extracellular signaling molecules that elicit a variety of pathophysiological pathways in retina through the activation of P2 and P1 purinoceptors, respectively.
Shan-Shan Ye, Yong Tang, Yong Tang, Jian-Tao Song   +3 more
doaj   +1 more source

Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain

Frontiers in Neurology
BackgroundSeveral studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management approach, the mechanism of electroacupuncture (EA) treatment of acidification-induced pain is
Qing Ye, Jie Li, Wen-Jing Ren, Ying Zhang, Tao Wang, Patrizia Rubini, Hai-Yan Yin, Peter Illes, Peter Illes, Yong Tang, Yong Tang   +10 more
doaj   +1 more source

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Pharmacological Research
Major depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang, Peter Illes   +4 more
doaj   +1 more source

Purinergic signalling in bone

Frontiers in Endocrinology, 2012
Purinergic signalling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells.
Robin Mark Howard Rumney, Ning eWang, Ankita eAgrawal, Alison eGartland   +3 more
doaj   +1 more source

Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is associated with elevated ATP levels in the extracellular space. Once released, ATP serves as danger signal modulating immune responses by activating purinergic receptors.
Sven Schneider, Irmgard Merfort, Marco Idzko, Andreas Zech   +3 more
doaj   +1 more source