Results 21 to 30 of about 7,662 (216)
Correcting an overactive exercise pressor reflex: A new role for purinergic signalling? [PDF]
Experimental PhysiologyFiona D. McBryde
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Purinergic Signaling during Inflammation [PDF]
New England Journal of Medicine, 2012 Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.
Holger K, Eltzschig +2 more
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Electroacupuncture prevents astrocyte atrophy to alleviate depression
Cell Death and Disease, 2023 Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive ...
Si-Si Lin +8 more
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Neonatal Seizures and Purinergic Signalling. [PDF]
Int J Mol Sci, 2020 Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-seizure medication potentiating brain ...
Menéndez Méndez A, Smith J, Engel T.
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Purinergic signaling in epilepsy [PDF]
Journal of Neuroscience Research, 2016 Until recently, analysis of the mechanisms underlying epilepsy was centered on neuron dysfunctions. Accordingly, most of the available pharmacological treatments aim at reducing neuronal excitation or at potentiating neuronal inhibition. These therapeutic options can lead to obvious secondary effects, and, moreover, seizures cannot be controlled by any
Rassendren, François, Audinat, Etienne
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British Journal of Pharmacology, 2006 While there were early papers about the extracellular actions of purines, the role of ATP as a purinergic neurotransmitter in nonadrenergic, noncholinergic nerves in the gut and bladder in 1972 was a landmark discovery, although it met considerable resistance for the next 20 years. In the early 1990s, receptors for purines were cloned: four P1 receptor
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Purinergic signalling and diabetes [PDF]
Purinergic Signalling, 2013 The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the balance is broken-cells can be starving in the midst of plenty. There are indications that the incidence of diabetes type 1 and 2, and possibly pancreatogenic diabetes, is ...
Burnstock, G, Novak, I
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P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease
Frontiers in Pharmacology, 2021 Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou +9 more
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Imbalance in the Expression of Genes Associated with Purinergic Signalling in the Lung and Systemic Arteries of COPD Patients. [PDF]
Sci Rep, 2019 Careta O +7 more
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Purinergic signalling and cancer [PDF]
Purinergic Signalling, 2013 Receptors for extracellular nucleotides are widely expressed by mammalian cells. They mediate a large array of responses ranging from growth stimulation to apoptosis, from chemotaxis to cell differentiation and from nociception to cytokine release, as well as neurotransmission.
Burnstock G, DI VIRGILIO, Francesco
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