Results 31 to 40 of about 12,719 (269)
Synthesis of 6-(2-hydroxyaryl)-2-pyridones by the reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides [PDF]
, 2013 A reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides in the presence of sodium ethoxide furnished a number of new 3-substituted 6-(2-hydroxyaryl)-2-pyridones in good yields, including those containing a polyfluoroalkyl group at ...
Anufriev, V. A. +2 more
core +1 more source
A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones [PDF]
, 2013 Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at -20 C for 2-21 days gave 5-amino-3-oxopent-4-enamides in 28-78% yields, which were cyclized with DMF-DMA ...
Obydennov, D. L. +3 more
core +1 more source
Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1 [PDF]
, 2015 Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of
Antonyuk, SV +10 more
core +1 more source
CXXXI.—Benzeneazo-2-pyridone [PDF]
J. Chem. Soc., Trans., 1908 n ...
Mills, William Hobson, Widdows, Sibyl T.
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2013 A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides.
Liquan Tan +3 more
doaj +1 more source
Directed diversity-oriented synthesis. Ring-fused 5- to 10-membered rings from a common peptidomimetic 2-pyridone precursor [PDF]
, 2012 A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis.
Almqvist, Fredrik +3 more
core +1 more source
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules, 2003 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga +4 more
doaj +1 more source
3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance
Molecules, 2022 3,4-Dihydro-2(1H)-pyridones (3,4-DHPo) and their derivatives are privileged structures, which has increased their relevance due to their biological activity in front of a broad range of targets, but especially for their importance as synthetic precursors
Sisa Chalán-Gualán +5 more
doaj +1 more source
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
core +2 more sources
Molecules, 2022 Dehydroacetic acid and triacetic acid lactone are known to be versatile substrates for the synthesis of a variety of azaheterocycles. However, their fluorinated analogs were poorly described in the literature.
Vladislav V. Fedin +3 more
doaj +1 more source