Results 31 to 40 of about 20,092 (323)

Ru(ii)-catalyzed C6-selective C–H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors

RSC Advances, 2020
In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(ii) complex.
Yangjie Fu, Zhaohui Wang, Qiyu Zhang, Zhiyu Li, Hong Liu, Xiaoling Bi, Jiang Wang   +6 more
semanticscholar   +1 more source

Reactions of Trifluorotriacetic Acid Lactone and Hexafluorodehydroacetic Acid with Amines: Synthesis of Trifluoromethylated 4-Pyridones and Aminoenones

Molecules, 2022
Dehydroacetic acid and triacetic acid lactone are known to be versatile substrates for the synthesis of a variety of azaheterocycles. However, their fluorinated analogs were poorly described in the literature.
Vladislav V. Fedin, Sergey A. Usachev, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

Tautomerism of 4-Pyridones [PDF]

Bulletin of the Chemical Society of Japan, 1977
Abstract The tautomeric constants, Kt, of several 4-pyridones were determined by measurement of pKa values. For 2-substituted 5-methoxy-4-pyridones, the Kt values were correlated to the substituent constants σ, the equation logkt=2.98+2.93σm−6.18σo being obtained.
Hiromichi Besso, Hisashi Matsumura, Kimiaki Imafuku   +2 more
openaire   +2 more sources

Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2001
A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the reaction
NATASA V. VALENTIC, GORDANA S. USCUMLIC, DUSAN Z. MIJIN   +2 more
doaj   +3 more sources

Modular Chiral N-Heterocyclic Carbene Ligands for the Nickel-Catalyzed Enantioselective C–H Functionalization of Heterocycles

CHIMIA, 2020
N-Heterocyclic carbenes (NHCs) are the ligands of choice in a large variety of transformations entailing different transition metals. However, the number and variety of chiral NHCs suitable as stereo-controlling ligands in asymmetric catalysis remains ...
Johannes Diesel, Nicolai Cramer
doaj   +1 more source

Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2019
In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical ...
Tadić Julijana, Mihajlović Marina, Jovanović Mića, Mijin Dušan   +3 more
doaj   +1 more source

Die Acylierung von 4‐Pyridon [PDF]

Chemische Berichte, 1980
AbstractBei der Acylierung von 4‐Pyridon (1) mit aliphatischen Carbonsäure‐anhydriden und ‐chloriden oder freien Säuren in Gegenwart von Dicyclohexylcarbodiimid erhält man ausschließlich N‐Acyl‐4‐pyridone (5). Auch bei der Umsetzung von 1 mit ortho‐substituierten Benzoesäurederivaten sind nur N‐Acylierungsprodukte 8 isolierbar.
Effenberger, Franz, Mück, Alfred Otto, Bessey, Eberhard   +2 more
openaire   +2 more sources

Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones [PDF]

, 2010
Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g.
A Filloux, A Zavialov, Alain Filloux, AV Zavialov, CCP4, D Choudhury, Dipshikha Chakravortty, DJ Hassett, E Chorell, ET Saulino, F Jacob-Dubuisson, FG Sauer, FG Sauer, G Waksman, Gabriel Waksman, GP Bodey, Guoyu Meng, H Hodak, H Remaut, I Vallet, J Mazar, J Tommassen, JG Bann, JL Veesenmeyer, JR Govan, JS Pinkner, JW St Geme 3rd, KW Dodson, MD Winn, MJ Kuehn, N Mesaros, P Watnick, R Fronzes, RA Engh, RA Laskowski, Rui Wang, S Ruer, S Ruer, TJ Knowles, WL DeLano, Xun Cai   +40 more
core   +8 more sources

3-Cyano-4,6-dimethyl-2-pyridone (Guareschi pyridone)

Acta Crystallographica Section E Structure Reports Online, 2004
In the crystal structure of the title compound, C8H8N2O, the mol­ecules form centrosymmetric dimers via N—H⋯O hydrogen bonds.
Victor B. Rybakov, Leonid A. Aslanov, Alexander A. Bush, Eugene V. Babaev   +3 more
openaire   +2 more sources

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]

, 2018
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael, Juan Rodríguez, Rocío, Kandil, Dalia, McGlacken, Gerard P., Pastor Cavada, Elena, Schellekens, Harriët, Shaban, Hamdy, Shanahan, Rachel, Torres-Fuentes, Cristina   +8 more
core   +3 more sources