Results 31 to 40 of about 20,827 (302)

An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide

Beilstein Journal of Organic Chemistry, 2013
A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides.
Liquan Tan, Peng Zhou, Cui Chen, Weibing Liu   +3 more
doaj   +1 more source

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Molecules, 2003
3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki   +4 more
doaj   +1 more source

Reactions of Trifluorotriacetic Acid Lactone and Hexafluorodehydroacetic Acid with Amines: Synthesis of Trifluoromethylated 4-Pyridones and Aminoenones

Molecules, 2022
Dehydroacetic acid and triacetic acid lactone are known to be versatile substrates for the synthesis of a variety of azaheterocycles. However, their fluorinated analogs were poorly described in the literature.
Vladislav V. Fedin, Sergey A. Usachev, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]

, 2018
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael, Juan Rodríguez, Rocío, Kandil, Dalia, McGlacken, Gerard P., Pastor Cavada, Elena, Schellekens, Harriët, Shaban, Hamdy, Shanahan, Rachel, Torres-Fuentes, Cristina   +8 more
core   +3 more sources

Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes

ACS Omega, 2020
Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes, respectively. In this work, a new series of N-sulfonamide 2-pyridone derivatives that combine
Rasha A. Azzam, Rasha E. Elsayed, G. Elgemeie   +2 more
semanticscholar   +1 more source

3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance

Molecules, 2022
3,4-Dihydro-2(1H)-pyridones (3,4-DHPo) and their derivatives are privileged structures, which has increased their relevance due to their biological activity in front of a broad range of targets, but especially for their importance as synthetic precursors
Sisa Chalán-Gualán, Vida Castro, Ruth Oropeza, Margarita Suárez, Fernando Albericio, Hortensia Rodríguez   +5 more
doaj   +1 more source

Enzymatic synthesis of vitamin B6 precursor [PDF]

, 2013
3-Cyano-4-ethoxymethyl-6-methyl-2-pyridone is an important precursor in the synthesis of vitamin B6, obtained in the addition reaction between 2-cyanoacetamide and 1-ethoxy-2,4-pentanedione catalyzed by lipase from Candida rugosa ...
Bezbradica Dejan I., Knežević-Jugović Zorica D., Mijin Dušan Ž., Prlainović Nevena Ž., Veličković Dušan V.   +4 more
core   +1 more source

Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2001
A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the reaction
NATASA V. VALENTIC, GORDANA S. USCUMLIC, DUSAN Z. MIJIN   +2 more
doaj   +3 more sources

Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1 [PDF]

, 2015
Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of
Antonyuk, SV, Berry, NG, Biagini, GA, Capper, MJ, Fisher, N, Hasnain, SS, Lawrenson, AS, Moss, D, O?Neill, PM, Strange, RW, Ward, SA   +10 more
core   +1 more source

Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones [PDF]

, 2010
Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g.
A Filloux, A Zavialov, Alain Filloux, AV Zavialov, CCP4, D Choudhury, Dipshikha Chakravortty, DJ Hassett, E Chorell, ET Saulino, F Jacob-Dubuisson, FG Sauer, FG Sauer, G Waksman, Gabriel Waksman, GP Bodey, Guoyu Meng, H Hodak, H Remaut, I Vallet, J Mazar, J Tommassen, JG Bann, JL Veesenmeyer, JR Govan, JS Pinkner, JW St Geme 3rd, KW Dodson, MD Winn, MJ Kuehn, N Mesaros, P Watnick, R Fronzes, RA Engh, RA Laskowski, Rui Wang, S Ruer, S Ruer, TJ Knowles, WL DeLano, Xun Cai   +40 more
core   +8 more sources