Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira +6 more
wiley +1 more source
Evaluation of chemical compounds for induction of male sterility in wheat (Triticum aestivum L.) [PDF]
The short-list of eleven chemical hybridizing agents (CHAs) showing 98% or more induction of male sterility were identified following application at the pre-meiotic stage of wheat.
Chakraborty, Kajal, Devakumar, C
core
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections [PDF]
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently.
Alibana-Clouser, F +38 more
core +4 more sources
A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin +7 more
wiley +1 more source
Controle de plantas daninhas na cultura do milho utilizando leucena (Leucaena leucocephala (Lam.) de wit). [PDF]
Avaliou-se o efeito da parte aérea da leucena, em condiçoes de casa de vegetação e campo, sobre o desenvolvimento de plantas daninhas, fitotoxicidade para o milho e acréscimo de nitrogênio para a cultura. Em casa de vegetação (vasos) foram avaliadas 25 t
PEREIRA FILHO, I. A. +2 more
core +1 more source
Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis [PDF]
Bacteria produce protein polymers on their surface called pili or fimbriae that serve either as attachment devices or as conduits for secreted substrates.
Waksman, Gabriel
core +1 more source
Nickel‐Catalyzed cine‐Substitution Toward Carbonyl Dance
A nickel‐catalyzed cine‐substitution enables a 1,2‐carbonyl translocation (“carbonyl dance”) at tetralone derivatives under mild conditions. This transformation proceeds through enolization and selective amination, followed by hydrolysis, to afford β‐tetralones bearing migrated carbonyl groups.
Eito Moriya +2 more
wiley +1 more source
Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran ...
Dieter Heber +2 more
doaj +1 more source
Asymmetric aerobic oxidative NHC-catalysed synthesis of dihydropyranones utilising a system of electron transfer mediators [PDF]
In the context of green chemistry, the replacement of high molecular weight stoichiometric oxidants with O2 is most desirable but difficult. Here, we report the asymmetric aerobic oxidative synthesis of dihydropyranones.
Axelsson, Anton +3 more
core +1 more source
The reactions of the common palladium precursors Pd(OAc)2 and PdCl2 and cooperating bipyridone ligands leads to well defined complexes which are general precatalysts for the direct C─H arylation of arenes, more active than Pd(OAc)2/ligand mixtures in nonpolar solvents.
Francisco Villalba +2 more
wiley +1 more source

