Results 41 to 50 of about 77,046 (386)
Frontiers in Oncology, 2022 BackgroundIt is well known that chronic inflammation can promote the occurrence and progression of cancer. As a type of proinflammatory death, pyroptosis can recast a suitable microenvironment to promote tumor growth.
Xi Zhang +7 more
doaj +1 more source
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +3 more sources
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Signal Transduction and Targeted Therapy, 2022 In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to ICIs, partly caused by the absence of tumor ...
W. Gao +4 more
semanticscholar +1 more source
NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]
, 2016 NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun +7 more
core +1 more source
Nature Communications, 2023 Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response and boosts antitumor immunity.
Liang Zhang +11 more
semanticscholar +1 more source
Uromodulin, Inflammasomes, and Pyroptosis [PDF]
Journal of the American Society of Nephrology, 2012 As a kidney-specific protein, uromodulin has fascinated nephrologists for decades.[1][1] Initially known as Tamm-Horsfall protein, uromodulin is secreted by distal tubules into the urine, where it is the most abundant protein under physiologic conditions.
Alberto Ortiz +2 more
openaire +3 more sources
Frontiers in Genetics, 2022 Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou +6 more
doaj +1 more source
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources
Journal of Hematology & Oncology, 2022 Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of ...
Xuhui Tong +8 more
semanticscholar +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources