Targeting pyroptosis as a preventive and therapeutic approach for stroke
Cell Death Discovery, 2023 Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic stroke.
Junpeng Long +17 more
semanticscholar +1 more source
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Mediators of Inflammation, 2023 Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang +9 more
doaj +1 more source
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis.
Journal of Inflammation Research, 2023 PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone.
Chunxia Shi +7 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong +10 more
doaj +1 more source
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation [PDF]
arXiv, 2023 Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles.
arxiv
A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer
Cell Death Discovery, 2021 Ovarian cancer (OC) is a highly malignant gynaecological tumour that has a very poor prognosis. Pyroptosis has been demonstrated in recent years to be an inflammatory form of programmed cell death.
Y. Ye, Qinjin Dai, H. Qi
semanticscholar +1 more source
Critical Care, 2021 Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived exosomes as a new subcellular entity acting as a fundamental link between PMN-driven inflammation and tissue
Yang Jiao +8 more
semanticscholar +1 more source
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Nature Immunology, 2020 Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD).
J. Hu +17 more
semanticscholar +1 more source
Pyroptosis: a new paradigm of cell death for fighting against cancer
Journal of experimental & clinical cancer research : CR, 2021 Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embryonic development, but also plays an important
Yixin Tan +9 more
semanticscholar +1 more source
Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
Frontiers in Aging Neuroscience, 2022 Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing attention.
Yuehua Huang +10 more
doaj +1 more source