Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +3 more sources
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Frontiers in Genetics, 2022 Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou +6 more
doaj +1 more source
Uromodulin, Inflammasomes, and Pyroptosis [PDF]
Journal of the American Society of Nephrology, 2012 As a kidney-specific protein, uromodulin has fascinated nephrologists for decades.[1][1] Initially known as Tamm-Horsfall protein, uromodulin is secreted by distal tubules into the urine, where it is the most abundant protein under physiologic conditions.
Maria Dolores, Sanchez-Niño +2 more
openaire +2 more sources
Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]
, 2017 The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke +14 more
core +2 more sources
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
BMC Molecular and Cell Biology, 2023 Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang +5 more
doaj +1 more source
NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]
, 2016 NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun +7 more
core +1 more source
Advanced NanoBiomed Research, 2023 Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding +4 more
doaj +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources