Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellAs a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Jiang B +6 more
europepmc +2 more sources
Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System. [PDF]
Aging CellThis study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Liu X +11 more
europepmc +2 more sources
Solid Phase Extraction of Pyrroloquinoline Quinone by Surface Modified Magnetic Nano Materials
Shipin gongye ke-ji, 2023 In this study, three kinds of nanomaterials with silanized or ion pair silanized surface modifications were synthesized, and the extraction and adsorption properties of these three materials for pyrroloquinoline quinone were studied.
Ke MA, Yuanhang CHENG
doaj +1 more source
Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]
, 1996 The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk, +6 more
core +4 more sources
Whole-genome sequence analysis of Bombella intestini LMG 28161T, a novel acetic acid bacterium isolated from the crop of a red-tailed bumble bee, Bombus lapidarius [PDF]
, 2016 The whole-genome sequence of Bombella intestini LMG 28161(T), an endosymbiotic acetic acid bacterium (AAB) occurring in bumble bees, was determined to investigate the molecular mechanisms underlying its metabolic capabilities.
Borremans, Wim +7 more
core +13 more sources
Heliyon, 2020 Pyrroloquinoline quinone (PQQ) is contained in fruits and vegetables and in human breast milk. It has been reported that PQQ has high reactivity and changes to an imidazole structure (imidazole pyrroloquinoline) by a reaction with an amino acid at a high
Yasue Yamada +6 more
doaj +1 more source
Pyrroloquinoline Quinone: A Novel Vitamin? [PDF]
Nutrition Reviews, 2009 Pyrroloquinoline quinone (PQQ), otherwise known as methoxatin, is a water-soluble, redox-cycling orthoquinone that was initially isolated from cultures of methylotropic bacteria. It has been found to be a cofactor of some bacterial alcohol dehydrogenases, and is present in many animal tissues.
A, Bishop, P M, Gallop, M L, Karnovsky
openaire +2 more sources
Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy
Molecules, 2020 Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive to therapeutic intervention.
Qi Zhang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Pyrroloquinoline quinone (PQQ) has been reported to exhibit cardioprotective and antioxidant activities. Accordingly, this study was developed to explore the effects of PQQ treatment on myocardial hypertrophy and the underlying mechanism of ...
Jiabin Zhou +14 more
doaj +1 more source
Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments [PDF]
Bulletin of Emergency and Trauma, 2019 Objective: To evaluate effects of pyrroloquinoline quinone (PQQ) on ischemia-reperfusion injury using a rat ovary model.Method: Thirty healthy female Wistar rats with 250g were randomized into five experimental groups (n = 6): Group SHAM: The rats ...
Pegah Parhizkar +3 more
doaj +1 more source