Results 11 to 20 of about 2,320,796 (216)

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells* [PDF]

Journal of Biological Chemistry, 2013
Background: TrkA is a transmembrane receptor tyrosine kinase for nerve growth factor. Results: TrkA forms a molecular complex with insulin receptor and IRS-1 to induce Akt and Erk5 phosphorylation.
T. Geetha, Shraddha D. Rege, Salome E Mathews, S. Meakin, M. White, J. Babu   +5 more
semanticscholar   +5 more sources

TrkA Co-Receptors: The Janus Face of TrkA?

Cancers, 2023
Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon   +2 more
openaire   +3 more sources

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

Frontiers in Molecular Neuroscience, 2023
IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases.
Daniele Narducci, Despoina Charou, Despoina Charou, Thanasis Rogdakis, Thanasis Rogdakis, Ioanna Zota, Ioanna Zota, Vivi Bafiti, Maria Zervou, Theodora Katsila, Achille Gravanis, Achille Gravanis, Kyriakos C. Prousis, Ioannis Charalampopoulos, Ioannis Charalampopoulos, Theodora Calogeropoulou   +15 more
doaj   +1 more source

High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair [PDF]

Journal of Biological Chemistry, 2022
Neurotrophin signaling is essential for normal nervous system development and adult function. Neurotrophins are secreted proteins that signal via interacting with two neurotrophin receptor types: the multifaceted p75 neurotrophin receptor and the tropomyosin receptor kinase receptors. In vivo, neurons compete for the limited quantities of neurotrophins,
Jacinta N. Conroy, E. Coulson
semanticscholar   +3 more sources

Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Frontiers in Molecular Neuroscience, 2023
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique, Laura Calvo-Enrique, Silvia Lisa, Silvia Lisa, Cristina Vicente-García, Cristina Vicente-García, Ruben Deogracias, Ruben Deogracias, Juan Carlos Arévalo, Juan Carlos Arévalo   +9 more
doaj   +1 more source

Nerve Growth Factor Signals via Preexisting TrkA Receptor Oligomers [PDF]

Biophysical Journal, 2002
Nerve growth factor (NGF) promotes neuronal survival and differentiation by activating TrkA receptors. Similar to other receptor tyrosine kinases, ligand-induced dimerization is thought to be required for TrkA receptor activation. To study this process, we expressed TrkA receptors in Xenopus laevis oocytes and analyzed their response to NGF by using a ...
Mischel, Paul S., Umbach, Joy A., Eskandari, Sepehr, Smith, Shane G., Gundersen, Cameron B., Zampighi, Guido A.   +5 more
openaire   +2 more sources

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Extended Ceramide Exposure Activates the trkA Receptor by Increasing Receptor Homodimer Formation [PDF]

Journal of Neurochemistry, 1999
Abstract: Binding of nerve growth factor (NGF) to the trkA tyrosine kinase receptor results in receptor homodimer formation, transphosphorylation, and kinase activation that supports neuronal differentiation and survival. We have shown previously that short‐term exposure of PC12 cells to brain‐derived neurotrophic factor or to C2‐ceramide activates a ...
I, MacPhee, P A, Barker
openaire   +2 more sources

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

PLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravanis   +8 more
doaj   +1 more source

Expression of β‐NGF and high‐affinity NGF receptor (TrKA) in llama (Lama glama) male reproductive tract and spermatozoa

Molecular Reproduction and Development, 2018
β‐Nerve growth factor (β‐NGF) is a seminal plasma element, responsible for inducing ovulation in camelids. The main organ of β‐NGF production remains nondescript. The aims of this study were to (a) characterize gene expression and protein localization of
L. Sari, R. Zampini, M. Argañaraz, M. Carretero, F. G. Fumuso, D. Barraza, M. Ratto, S. Apichela   +7 more
semanticscholar   +1 more source