Results 21 to 30 of about 2,320,796 (216)
NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]
PLoS ONE, 2012 Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor +3 more
doaj +1 more source
TrkA glycosylation regulates receptor localization and activity
Journal of Neurobiology, 1999 The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Watson, F. L. +4 more
openaire +2 more sources
Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
eLife, 2018 The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye +2 more
doaj +1 more source
NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. [PDF]
PLoS ONE, 2009 BACKGROUND:Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs.
Sreekumar Othumpangat +3 more
doaj +1 more source
Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA
Molecular Therapy: Methods & Clinical Development, 2023 Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli +5 more
doaj +1 more source
Production of a Monoclonal Antibody Directed against the High-Affinity Nerve Growth Factor Receptor
The International Journal of Biological Markers, 1999 The high-affinity nerve growth factor receptor corresponds to the tyrosine protein kinase encoded by the proto-oncogene trkA. Different findings suggest that nerve growth factor (NGF) can be operative in the growth modulation of tumor cell lines ...
E. Tagliabue +8 more
doaj +1 more source
Frontiers in Chemistry, 2023 Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar +20 more
doaj +1 more source
Functional expression of TrkA receptors in hippocampal neurons
Journal of Neuroscience Research, 1998 Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NIH 3T3, COS, and PC12 cells.
Aibel, Lani +3 more
openaire +3 more sources
TrkA Receptor Endolysosomal Degradation is Both Ubiquitin and Proteasome Dependent [PDF]
Traffic, 2008 Gaps in our knowledge exist regarding the degradation of the tropomyosin‐regulated kinase A (TrkA) receptor after addition of neurotrophin, nerve growth factor (NGF). TrkA is rapidly and transiently ubiquitinated upon addition of NGF.
Thangiah, Geetha, Marie W, Wooten
openaire +2 more sources
Communications Biology, 2020 Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA.
Shu Zhao +10 more
doaj +1 more source