Results 41 to 50 of about 2,320,796 (216)

CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase [PDF]

Neuron, 2009
The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism. Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the ...
Harel, Liraz, Costa, Barbara, Tcherpakov, Marianna, Zapatka, Marc, Oberthuer, Andre, Hansford, Loen M., Vojvodic, Milijana, Levy, Zehava, Chen, Zhe-Yu, Lee, Francis S., Avigad, Smadar, Yaniv, Isaac, Shi, Leming, Eils, Roland, Fischer, Matthias, Brors, Benedikt, Kaplan, David R., Fainzilber, Mike   +17 more
openaire   +2 more sources

Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice

iScience, 2023
Summary: In mature bone, NGF is produced by osteoblasts following mechanical loading and signals through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), to support bone formation.
Ibtesam Rajpar, Gaurav Kumar, Paolo Fortina, Ryan E. Tomlinson   +3 more
doaj   +1 more source

TrkA neutrophin receptor protein in the rat and human thymus [PDF]

The Anatomical Record, 1997
Increasing evidence suggests that nerve growth factor (NGF), and probably other neurotrophins, are involved in the control of lymphoid organs and immunocompetent cells that express neurotrophins and/or their receptors. In the rat thymus, mRNA for TrkA (an essential component of the NGF signal transducing receptor) has been found primarily in stromal ...
J, Hannestad, O, García-Suárez, J J, Huerta, I, Esteban, F J, Naves, J A, Vega   +5 more
openaire   +2 more sources

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source

Endosomal pH in Neuronal Signaling and Synaptic Transmission: Role of Na+/H+ Exchangers

Frontiers in Physiology, 2014
Neuronal precursor cells extend multiple neurites during development, one of which extends to form an axon whereas others develop into dendrites. Chemical stimulation of N-methyl D-aspartate (NMDA) receptor in fully-differentiated neurons induces ...
Graham H Diering, Masayuki eNumata
doaj   +1 more source

Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation [PDF]

Glycobiology, 2004
Trypanosome trans-sialidase (TS) is a sialic acid-transferring enzyme that hydrolyzes alpha2,3-linked sialic acids and transfers them to acceptor molecules. Here we show that a highly purified recombinant TS derived from T. cruzi parasites targets TrkA receptors on TrkA-expressing PC12 cells and colocalizes with TrkA internalization and phosphorylation
Alicja, Woronowicz, Kristof, De Vusser, Wouter, Laroy, Roland, Contreras, Susan O, Meakin, Gregory M, Ross, Myron R, Szewczuk   +6 more
openaire   +2 more sources

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma

Molecular Oncology, 2017
Nucleophosmin‐anaplastic lymphoma kinase‐expressing (NPM‐ALK+) T‐cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM‐ALK+ T‐cell lymphoma is not completely understood.
Wenyu Shi, Suraj Konnath George, Bhawana George, Choladda V. Curry, Albina Murzabdillaeva, Serhan Alkan, Hesham M. Amin   +6 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Biology Open, 2013
Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor.
Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi   +2 more
doaj   +1 more source

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source