Results 41 to 50 of about 22,923 (160)

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source

TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors [PDF]

, 1906
SummaryPrimary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits ...
Wheeler, Michael A., Heffner, Danielle L., Kim, Suemin, Espy, Sarah M., Spano, Anthony J., Cleland, Corey L., Deppmann, Christopher D.   +6 more
core   +1 more source

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Biology Open, 2013
Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor.
Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi   +2 more
doaj   +1 more source

Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat

European Journal of Histochemistry, 2009
Nerve Growth Factor (NGF) is a member of the neurotrophin family. Neurotrophins exert their effects by binding to corresponding receptors, which are formed by the tyrosine protein kinases TrkA, TrkB, and TrkC, and the low affinity p75NTR receptor.
C. Squillacioti, A. De Luca, S. Paino, E. Langella, N. Mirabella   +4 more
doaj   +3 more sources

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma

Molecular Oncology, 2017
Nucleophosmin‐anaplastic lymphoma kinase‐expressing (NPM‐ALK+) T‐cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM‐ALK+ T‐cell lymphoma is not completely understood.
Wenyu Shi, Suraj Konnath George, Bhawana George, Choladda V. Curry, Albina Murzabdillaeva, Serhan Alkan, Hesham M. Amin   +6 more
doaj   +1 more source

Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts. [PDF]

PLoS ONE, 2012
In the conjunctiva, repeated or prolonged exposure to injury leads to tissue remodeling and fibrosis associated with dryness, lost of corneal transparency and defect of ocular function.
Alessandra Micera, Ilaria Puxeddu, Bijorn Omar Balzamino, Stefano Bonini, Francesca Levi-Schaffer   +4 more
doaj   +1 more source

The impact of high density receptor clusters on VEGF signaling [PDF]

EPTCS 125, 2013, pp. 37-52, 2013
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv   +1 more source

Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms [PDF]

, 2015
Publisher Copyright: © 2015 Luberg et al.Background: Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family.
A Bonacchi, A Eggert, A Gong, A Jerónimo-Santos, A Salehi, A Tacconelli, A Tacconelli, AM Davies, AM Fagan, AR Farina, B Davidson, B Talcott, C Hock, C Lagadec, C Matrone, C Nassenstein, CR Sanna, CY Ni, D Chuderland, D Martin-Zanca, D Puehringer, DO Clary, DR Kaplan, E Díaz-Rodríguez, EJ Huang, Elina Aleksejeva, F Coulier, F Marmigère, FF Hefti, FL Watson, FS Lee, FS Lee, G Blobel, I Bongarzone, J Chen, J Jullien, JR Gomes, K Luberg, Kristi Luberg, L Minichiello, M Ohmichi, M Sepp, M-R Ho, MA Lemmon, MV Chao, ND Freedman, O Gimm, OG Vidaurre, P Dubus, PA Barker, R Rajagopal, R Schneider, R Urfer, Rahel Park, RM Stroud, RR Reinhardt, SD Ginsberg, SD Skaper, SE Calvo, SO Meakin, T Rantamäki, Tõnis Timmusk, V Freund-Michel, V Veeramachaneni, VA Flørenes, X Yao, X-Q Wang, Y Indo, Y Miura, Y Okazaki   +69 more
core   +2 more sources

High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]

Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv   +1 more source