Results 71 to 80 of about 2,320,796 (216)
Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source
Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2014 The nerve growth factor (NGF) pathway has been shown to play a key role in pain treatment. Recently, a systems pharmacology model has been proposed that can aid in the identification and validation of drug targets in the NGF pathway. However, this model did not include the role of the p75 receptor, which modulates the signaling of NGF through the ...
Toni, T, Dua, P, van der Graaf, P H
openaire +2 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang +5 more
wiley +1 more source
Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
Cell Reports, 2016 The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The
Damir Omerbašić +9 more
doaj +1 more source
Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma
Global Challenges, Volume 10, Issue 1, January 2026.This article comprehensively examines the evolving landscape of systemic therapy for advanced hepatocellular carcinoma. It covers the progress in tyrosine kinase inhibitors and immune checkpoint inhibitors, analyzes the efficacy of novel combination strategies, and discusses current challenges like drug resistance and the lack of biomarkers.
Yongxin Yu +5 more
wiley +1 more source
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 1, January 2026.ABSTRACT Emerging neurotrophin treatments for optic nerve injury (ONI) aim to prevent the loss of retinal ganglion cells (RGCs) and enhance axonal regeneration. Microneurotrophins (MNTs), small‐molecule mimetics of neurotrophins, have shown neuroprotective effects in various animal models of neurodegeneration, yet MNT effects on ONI remain unknown ...
K. Georgelou +13 more
wiley +1 more source
Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. [PDF]
PLoS ONE, 2012 Receptor tyrosine kinase signaling cooperates with WNT/β-catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined.
Pavel Krejci +19 more
doaj +1 more source
Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity
Lifestyle Medicine, Volume 7, Issue 1, January 2026.ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien +4 more
wiley +1 more source
In vitro effect of nerve growth factor on the main traits of rabbit sperm
Reproductive Biology and Endocrinology, 2019 Background The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role not only in the nervous but also in other non-nervous systems such as the reproductive system. The aim of the paper is to study the in vitro effect of
Cesare Castellini +9 more
doaj +1 more source