Results 51 to 60 of about 836,416 (221)

Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions

Journal of Gene Medicine, 2012
The genetic engineering of T cells through the introduction of a chimeric antigen receptor (CAR) allows for generation of tumor‐targeted T cells. Once expressed by T cells, CARs combine antigen‐specificity with T cell activation in a single fusion ...
K. Curran, Hollie J. Pegram, R. Brentjens   +2 more
semanticscholar   +1 more source

A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies.

Blood, 2015
Options for targeted therapy of T-cell malignancies remain scarce. Recent clinical trials demonstrated that chimeric antigen receptors (CARs) can effectively redirect T lymphocytes to eradicate lymphoid malignancies of B-cell origin.
Maksim Mamonkin, R. Rouce, Haruko Tashiro, M. Brenner   +3 more
semanticscholar   +1 more source

Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions

Frontiers in Cell and Developmental Biology, 2020
Dynamic localization of receptors and signaling molecules at the plasma membrane and within intracellular vesicular compartments is crucial for T lymphocyte sensing environmental cues, triggering membrane receptors, recruiting signaling molecules, and ...
Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Andrés Alcover, Vincenzo Di Bartolo   +4 more
doaj   +1 more source

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. [PDF]

PLoS ONE, 2012
Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have already shown clinical benefit for cancer patients.
Lukas Baitsch, Amandine Legat, Leticia Barba, Silvia A Fuertes Marraco, Jean-Paul Rivals, Petra Baumgaertner, Céline Christiansen-Jucht, Hanifa Bouzourene, Donata Rimoldi, Hanspeter Pircher, Nathalie Rufer, Maurice Matter, Olivier Michielin, Daniel E Speiser   +13 more
doaj   +1 more source

Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol

Frontiers in Cell and Developmental Biology, 2021
Biological membranes consist of hundreds of different lipids that together with the embedded transmembrane (TM) proteins organize themselves into small nanodomains.
Salma Pathan-Chhatbar, Salma Pathan-Chhatbar, Salma Pathan-Chhatbar, Carina Drechsler, Carina Drechsler, Carina Drechsler, Kirsten Richter, Anna Morath, Anna Morath, Anna Morath, Wei Wu, Bo OuYang, Chenqi Xu, Chenqi Xu, Wolfgang W. Schamel, Wolfgang W. Schamel, Wolfgang W. Schamel   +16 more
doaj   +1 more source

Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.

Molecular Therapy, 2010
To enhance the strength of activation afforded by tumor antigen-specific receptors, we investigated the effect of adding combined CD28 and 4-1BB costimulatory signaling domains to a chimeric antigen receptor (CAR) specific for prostate-specific membrane ...
Xiao-song Zhong, M. Matsushita, J. Plotkin, I. Rivière, M. Sadelain   +4 more
semanticscholar   +1 more source

Diverse and reprogrammable mechanisms of malignant cell transformation in lymphocytes: pathogenetic insights and translational implications

Frontiers in Oncology
While normal B- and T-lymphocytes require antigenic ligands to become activated via their B- and T-cell receptors (BCR and TCR, respectively), B- and T-cell lymphomas show the broad spectrum of cell activation mechanisms regarding their dependence on BCR
Mariusz A. Wasik, Patricia M. Kim, Reza Nejati   +2 more
doaj   +1 more source

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.

PLoS ONE, 2019
Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells.
Jieming Zeng, Shin Yi Tang, Shu Wang
doaj   +1 more source

Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy.

PLoS ONE, 2014
While much of cancer immunology research has focused on anti-tumor immunity both systemically and within the tumor microenvironment, little is known about the impact of pre-existing malignancy on pathogen-specific immune responses.
Rohit Mittal, Maylene Wagener, Elise R Breed, Zhe Liang, Benyam P Yoseph, Eileen M Burd, Alton B Farris, Craig M Coopersmith, Mandy L Ford   +8 more
doaj   +1 more source

Rational design of T cell receptors with enhanced sensitivity for antigen. [PDF]

PLoS ONE, 2011
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches.
Rajshekhar Alli, Ziwei M Zhang, Phuong Nguyen, Jie J Zheng, Terrence L Geiger   +4 more
doaj   +1 more source