Results 61 to 70 of about 836,416 (221)
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires [PDF]
, 2017 The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV).
arxiv +1 more source
Rare event simulation for T-cell activation [PDF]
J. Stat. Phys. 134 (2009), 537-566, 2009 The problem of \emph{statistical recognition} is considered, as it arises in immunobiology, namely, the discrimination of foreign antigens against a background of the body's own molecules. The precise mechanism of this foreign-self-distinction, though one of the major tasks of the immune system, continues to be a fundamental puzzle. Recent progress has
arxiv +1 more source
Nanodrugs Targeting T Cells in Tumor Therapy
Frontiers in Immunology, 2022 In contrast to conventional anti-tumor agents, nano-carriers allow co-delivery of distinct drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic approaches aim to target and kill tumor cells directly or to address antigen ...
Maximilian Haist +2 more
doaj +1 more source
Dynamic Kernel Matching for Non-conforming Data: A Case Study of T-cell Receptor Datasets [PDF]
arXiv, 2021 Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we describe an approach for modifying established statistical classifiers to handle non-conforming data, which we call ...
arxiv
Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires [PDF]
Mol. Syst. Des. Eng. (2019), 2019 The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled via adaptive B- and T-cell receptors: the immune receptor repertoire.
arxiv +1 more source
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
Proceedings of the National Academy of Sciences of the United States of America, 2008 Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the maintenance of peripheral immune tolerance. Release from PD-
D. Y. Lin +9 more
semanticscholar +1 more source
Functional Development of the T Cell Receptor for Antigen [PDF]
, 2010 For over three decades now, the T cell receptor (TCR) for antigen has not ceased to challenge the imaginations of cellular and molecular immunologists alike. T cell antigen recognition transcends every aspect of adaptive immunity: it shapes the T cell repertoire in the thymus and directs T cell-mediated effector functions in the periphery, where it is ...
Qi-Jing Li +3 more
openaire +3 more sources
Haematologica, 2020 Allogeneic hematopoietic stem cell transplantation is an effective therapy for high-risk leukemias. In children, graft manipulation based on the selective removal of αβ T cells and B cells has been shown to reduce the risk of acute and chronic graft ...
Volker Wiebking +8 more
doaj +1 more source
Engineering strategies to overcome the current roadblocks in CAR T cell therapy
Nature Reviews Clinical Oncology, 2019 T cells genetically engineered to express chimeric antigen receptors (CARs) have proven — and impressive — therapeutic activity in patients with certain subtypes of B cell leukaemia or lymphoma, with promising efficacy also demonstrated in patients with ...
S. Rafiq +2 more
semanticscholar +1 more source
Journal of Immunology, 1984 By using as an experimental system the induction of growth of a cloned, antigen:Ia-reactive helper T cell line by an antigen receptor-specific monoclonal antibody, we demonstrated that growth requires two essential co-factors, exogenously produced IL 1 ...
J. Kaye +7 more
semanticscholar +1 more source