Endocrine Disruptors and Breast Cancer: A Comprehensive Review [PDF]
BiomedicinesBreast cancer is one of the most prevalent malignancies affecting women worldwide. Among environmental risk factors, increasing attention has been given to endocrine-disrupting chemicals (EDCs), which can interfere with hormonal signaling pathways ...
Luiza Czaczkowska +2 more
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The Pharmacological Evidences for the Involvement of AhR and GPR35 Receptors in Kynurenic Acid-Mediated Cytokine and Chemokine Secretion by THP-1-Derived Macrophages [PDF]
MoleculesKynurenic acid (KYNA), a tryptophan metabolite, possesses immunomodulatory properties, although the molecular mechanism of this action has not yet been resolved.
Katarzyna Sawa-Wejksza +2 more
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Clinical Value of Serum Mitochondria-Inhibiting Substances in Assessing Renal Hazards: A Community-Based Prospective Study in Korea [PDF]
Endocrinology and Metabolism, 2021 Background Mitochondrial dysfunction is strongly associated with several kidney diseases. However, no studies have evaluated the potential renal hazards of serum mitochondria-inhibiting substance (MIS) and aryl hydrocarbon receptor ligand (AhRL) levels ...
Hoon Sung Choi +5 more
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Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors
Medicine in Microecology, 2023 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that serves as a key environmental sensor and mechanistic regulator of both the epithelial barrier and systemic immunity. Exogenous ligands (aromatic compounds such as dioxins)
Zhipeng Huang, Liwei Xie, Liping Huang
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Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss [PDF]
Anais Brasileiros de Dermatologia, 2017 The etiopathogenesis of female pattern hair loss is still poorly understood. In addition to genetic and hormonal elements, environmental factors could be involved.
Paulo Müller Ramos +5 more
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AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors
Cells, 2023 Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli +2 more
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Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
Acta Medica Bulgarica, 2021 Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR).
Andreeva-Gateva P. +7 more
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Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
Biomedicines, 2022 The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs;
Han-Bi Kim +6 more
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Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?
Reports, 2023 In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more than a norepinephrine precursor, was a brain neurotransmitter in and of itself.
Adonis Sfera
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Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris
Frontiers in Microbiology, 2022 Acne vulgaris is a chronic inflammatory skin disease in which the influence of gut microbiota has been implicated but without clarification of mechanisms. Gut microbiota may exert such an influence via metabolites, particularly those of tryptophan.
Yukun Huang +6 more
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