Results 11 to 20 of about 19,892 (167)
The aryl hydrocarbon receptor in liver inflammation [PDF]
Seminars in Immunopathology, 2021 AbstractThe aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated transcription factor with multifaceted physiological functions. In the immune system, AHR has been unequivocally identified as a key regulatory factor that can integrate environmental, dietary, or microbial signals into innate and adaptive immune responses ...
Antonella Carambia, Fenja Amrei Schuran
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The aryl hydrocarbon receptor system [PDF]
dmdi, 2012 Abstract The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. Recent evidence suggests that this receptor also has important endogenous functions subsequent to activation by natural dietary ...
Barouki, Robert +3 more
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High Serum-Induced AhRL Is Associated with Prevalent Metabolic Syndrome and Future Impairment of Glucose Tolerance in the Elderly [PDF]
Endocrinology and Metabolism, 2021 Background High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.
Youngmi Kim Pak +6 more
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Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
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Nuclear receptors: a bridge linking the gut microbiome and the host
Molecular Medicine, 2021 Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang +2 more
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Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond
Pharmacological Research, 2023 In the aftermath of tissue injury or infection, an efficient resolution mechanism is crucial to allow tissue healing and preserve appropriate organ functioning. Pro-resolving bioactive lipids prevent uncontrolled inflammation and its consequences.
Sergio Sánchez-García +5 more
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AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish.
PLoS ONE, 2012 The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years.
Britton C Goodale +5 more
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Frontiers in Immunology, 2020 ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
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Frontiers in Immunology, 2022 Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels.
Xiaoyu Xi +15 more
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AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor
Nature Communications, 2017 In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen +5 more
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