Results 21 to 30 of about 19,892 (167)
Frontiers in Microbiology, 2021 National screening programs use dried blood specimens to detect metabolic disorders or aberrant protein functions that are not clinically evident in the neonatal period.
Anne-Christine Aust +10 more
doaj +1 more source
Xenobiotic receptors in mediating the effect of sepsis on drug metabolism
Acta Pharmaceutica Sinica B, 2020 Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways.
Chuanzhu Lv, Ling Huang
doaj +1 more source
Role of gut microbiota-derived signals in the regulation of gastrointestinal motility
Frontiers in Medicine, 2022 The gastrointestinal (GI) tract harbors trillions of commensal microbes, called the gut microbiota, which plays a significant role in the regulation of GI physiology, particularly GI motility.
Zhipeng Zheng +3 more
doaj +1 more source
Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor
Frontiers in Immunology, 2023 The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins.
Eric Y. Helm, Liang Zhou
doaj +1 more source
The Aryl Hydrocarbon Receptor and Tumor Immunity [PDF]
Frontiers in Immunology, 2018 The aryl hydrocarbon receptor (AhR) is an important cytosolic, ligand-dependent transcription factor. Emerging evidence suggests the promoting role of the AhR in the initiation, promotion, progression, invasion, and metastasis of cancer cells. Studies on various tumor types and tumor cell lines have shown high AhR expression, suggesting that AhR is ...
Ping Xue +3 more
openaire +3 more sources
The aryl hydrocarbon receptor in tumor immunity [PDF]
OncoImmunology, 2012 The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR.
Platten, Michael +2 more
openaire +2 more sources
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
Frontiers in Immunology, 2021 The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer.
Adaobi Amobi-McCloud +18 more
doaj +1 more source
Dopamine is an aryl hydrocarbon receptor agonist
Biochemical Journal, 2020 Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and ...
Hyejin Park +8 more
openaire +2 more sources
环境与职业医学, 2023 BackgroundDue to the limited availability of established research models, very few studies addressed the health effects and underlying mechanisms following exposure to diesel exhaust during the initiation of pulmonary respiration.
Hao NI +4 more
doaj +1 more source
Cell Reports, 2018 Summary: The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free and conventionally raised mice
Smitha Krishnan +9 more
doaj +1 more source