Results 41 to 50 of about 19,892 (167)
Toxins, 2019 Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m2. Patients with CKD have high rates of complications and comorbidities.
Tacy Santana Machado +2 more
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Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants [PDF]
Plant Biotechnology Journal, 2009 SummaryDioxin residues widely contaminate soil and agricultural products at low concentrations and may accumulate in organisms at the top of food chains owing to their physicochemical properties. In this study, we have developed novel, dioxin‐inducible, reporter gene expression systems regulated by recombinant aryl hydrocarbon receptors (AhRs).
Susumu, Kodama +4 more
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Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation
Toxins, 2022 Uremic metabolites, molecules either produced by the host or from the microbiota population existing in the gastrointestinal tract that gets excreted by the kidneys into urine, have significant effects on both health and disease.
Avra Melina Madella +4 more
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New Trends in Aryl Hydrocarbon Receptor Biology [PDF]
Frontiers in Cell and Developmental Biology, 2016 Traditionally considered as a critical intermediate in the toxic and carcinogenic response to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (AhR) has proven to be also an important regulator of cell physiology and organ homeostasis.
Mulero-Navarro, Sonia +1 more
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The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors
Frontiers in OncologyCancer cells can alter their metabolism to meet energy and molecular requirements due to unfavorable environments with oxygen and nutritional deficiencies. Therefore, metabolic reprogramming is common in a tumor microenvironment (TME).
Zhiying Wang +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang +8 more
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Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors
Acta Pharmaceutica Sinica B, 2012 Oxazaphosphorines, with the most representative members including cyclophosphamide, ifosfamide, and trofosfamide, constitute a class of alkylating agents that have a broad spectrum of anticancer activity against many malignant ailments including both ...
Duan Wang, Hongbing Wang
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Staphylococcus aureus Activates the Aryl Hydrocarbon Receptor in Human Keratinocytes
Journal of Innate Immunity, 2022 Staphylococcus aureus is an important pathogen causing various infections, including – as most frequently isolated bacterium – cutaneous infections. Keratinocytes as the first barrier cells of the skin respond to S.
Eva-Lena Stange +6 more
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The Aryl Hydrocarbon Receptor [PDF]
Transplantation, 2013 The aryl hydrocarbon receptor (AHR), which has been central to studies in toxicology for years as the receptor for the toxicant dioxin, is rapidly gaining interest in immunology based on its ability to influence T-cell differentiation. Multiple studies have documented that binding of this receptor with certain ligands favors T-cell differentiation ...
Michael, Van Voorhis +3 more
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Antioxidant Functions of the Aryl Hydrocarbon Receptor [PDF]
Stem Cells International, 2016 The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix‐loop‐helix/PER‐ARNT‐SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands.
openaire +3 more sources