Results 51 to 60 of about 34,222 (298)
New Trends in Aryl Hydrocarbon Receptor Biology [PDF]
Frontiers in Cell and Developmental Biology, 2016 Traditionally considered as a critical intermediate in the toxic and carcinogenic response to dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (AhR) has proven to be also an important regulator of cell physiology and organ homeostasis.
Mulero-Navarro, Sonia +1 more
openaire +3 more sources
The aryl hydrocarbon receptor in liver inflammation [PDF]
Seminars in Immunopathology, 2021 AbstractThe aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated transcription factor with multifaceted physiological functions. In the immune system, AHR has been unequivocally identified as a key regulatory factor that can integrate environmental, dietary, or microbial signals into innate and adaptive immune responses ...
Antonella Carambia, Fenja Amrei Schuran
openaire +3 more sources
Cells, 2020 Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting +2 more
doaj +1 more source
Estrogen receptor and aryl hydrocarbon receptor signaling pathways [PDF]
Nuclear Receptor Signaling, 2006 Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds.
Matthews, Jason, Gustafsson, Jan-Åke
openaire +2 more sources
Cell Reports, 2018 Summary: The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free and conventionally raised mice
Smitha Krishnan +9 more
doaj +1 more source
Metformin reverses development of pulmonary hypertension via aromatase inhibition [PDF]
, 2016 Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP ...
Dean, Afshan +4 more
core +2 more sources
Role of aryl hydrocarbon receptors in infection and inflammation
Frontiers in ImmunologyThe aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances.
Linglan Xu +7 more
doaj +1 more source
Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics
Frontiers in Microbiology, 2022 The incidence and prevalence of inflammatory disorders have increased globally, and is projected to double in the next decade. Gut microbiome-based therapeutics have shown promise in ameliorating chronic inflammation.
Lokanand Koduru +7 more
doaj +1 more source
Signaling in a polluted world: oxidative stress as an overlooked mechanism linking contaminants to animal communication [PDF]
, 2016 The capacity to communicate effectively with other individuals plays a critical role in the daily life of an individual and can have important fitness consequences.
Costantini, David, Marasco, Valeria
core +1 more source
Microbial carcinogenic toxins and dietary anti-cancer protectants [PDF]
, 2017 Several toxins are known which account for the ability of some bacteria to initiate or promote carcinogenesis. These ideas are summarised and evidence is discussed for more specific mechanisms involving chymotrypsin and the bacterial chymotryptic enzyme ...
Darlington, L. Gail, Stone, Trevor W.
core +2 more sources