Results 31 to 40 of about 19,892 (167)
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
Frontiers in Immunology, 2021 Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that uptake and metabolize Trp to also generate important signaling ...
Heather M. Grifka-Walk +2 more
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Role of aryl hydrocarbon receptors in infection and inflammation
Frontiers in ImmunologyThe aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances.
Linglan Xu +7 more
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Cells, 2020 Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Philip Marx-Stoelting +2 more
doaj +1 more source
Aryl hydrocarbon receptor and intestinal immunity [PDF]
Mucosal Immunology, 2018 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated.
Lamas, Bruno +2 more
openaire +3 more sources
The Aryl Hydrocarbon Receptor in Asthma: Friend or Foe? [PDF]
International Journal of Molecular Sciences, 2020 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has emerged as an important player in asthma control. AhR is responsive to environmental molecules and endogenous or dietary metabolites and regulates innate and adaptive immune responses.
Poulain-Godefroy, Odile +5 more
openaire +4 more sources
The Aryl Hydrocarbon Receptor and the Nervous System [PDF]
International Journal of Molecular Sciences, 2018 The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR nuclear translocator). The heterodimer is a transcription factor, which regulates the transcription of xenobiotic metabolizing enzymes.
Ludmila Juricek, Xavier Coumoul
openaire +2 more sources
Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics
Frontiers in Microbiology, 2022 The incidence and prevalence of inflammatory disorders have increased globally, and is projected to double in the next decade. Gut microbiome-based therapeutics have shown promise in ameliorating chronic inflammation.
Lokanand Koduru +7 more
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The aryl hydrocarbon receptor and food allergy [PDF]
Veterinary Quarterly, 2013 The immune system is important for protection against pathogens and malignant cells. However, malfunction of the immune system can also result in detrimental auto-immune diseases, inflammatory diseases, cancers and allergies. The aryl hydrocarbon receptor (AhR), present in numerous tissues and cell subsets, including cells of the immune system, plays ...
Schulz, V.J. +2 more
openaire +3 more sources
Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass.
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj +1 more source
Frontiers in Immunology, 2023 Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and aryl ...
Gillian Dao Nyesiga +10 more
doaj +1 more source