AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors
Cells, 2023 Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors.
Leonida Rakateli +2 more
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Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
Acta Medica Bulgarica, 2021 Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR).
Andreeva-Gateva P. +7 more
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Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
Biomedicines, 2022 The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs;
Han-Bi Kim +6 more
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Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?
Reports, 2023 In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more than a norepinephrine precursor, was a brain neurotransmitter in and of itself.
Adonis Sfera
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A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors.
Toxicological Sciences, 2020 Over the last two decades, the zebrafish (Danio rerio) has emerged as a stellar model for unraveling molecular signaling events mediated by the Aryl Hydrocarbon Receptor (AHR), an important ligand-activated receptor found in all eumetazoan animals ...
P. Shankar +3 more
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Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris
Frontiers in Microbiology, 2022 Acne vulgaris is a chronic inflammatory skin disease in which the influence of gut microbiota has been implicated but without clarification of mechanisms. Gut microbiota may exert such an influence via metabolites, particularly those of tryptophan.
Yukun Huang +6 more
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High Serum-Induced AhRL Is Associated with Prevalent Metabolic Syndrome and Future Impairment of Glucose Tolerance in the Elderly [PDF]
Endocrinology and Metabolism, 2021 Background High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.
Youngmi Kim Pak +6 more
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Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). [PDF]
PLoS ONE, 2017 The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor conserved across phyla from flies to humans. Activated by a number of endogenous ligands and environmental toxins, studies on AHR function and gene regulation have ...
Wade W Sugden +3 more
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Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
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The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model [PDF]
, 2020 Author Posting. © American Chemical Society, 2020. This is an open access article published under an ACS AuthorChoice License. The definitive version was published in Chemical Research in Toxicology, 33(4), (2020): 860-879, doi:10.1021/acs.chemrestox ...
Avilla, Mele N. +4 more
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