Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics
Frontiers in Microbiology, 2022 The incidence and prevalence of inflammatory disorders have increased globally, and is projected to double in the next decade. Gut microbiome-based therapeutics have shown promise in ameliorating chronic inflammation.
Lokanand Koduru +7 more
doaj +1 more source
A tripartite of immune-, epithelial-, and nervous-systems in the homeostatic regulation of the gut [PDF]
, 2016 Various cell types in the intestinal mucosa are constantly exposed to complex signals emanating from the lumen, including the microbiota and its metabolites.
Chng, Song Hui
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Studies on gender-specific disruption of bone tissue homeostasis by dioxins [PDF]
, 2010 Dioxins are widespread environmental pollutants, known to cause immunosuppression, developmental and reproductive defects, as well as cancer. The toxic effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR, also referred to as the ...
Wejheden, Carolina
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Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants [PDF]
Plant Biotechnology Journal, 2009 SummaryDioxin residues widely contaminate soil and agricultural products at low concentrations and may accumulate in organisms at the top of food chains owing to their physicochemical properties. In this study, we have developed novel, dioxin‐inducible, reporter gene expression systems regulated by recombinant aryl hydrocarbon receptors (AhRs).
Susumu, Kodama +4 more
openaire +2 more sources
BMC Complementary and Alternative Medicine / Lupinalbin A as the most potent estrogen receptor \u3b1- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae) [PDF]
, 2014 Background: Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to exhibit estrogenic and aryl ...
Ateba, Sylvin Benjamin +6 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Frontiers in Immunology, 2023 Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and aryl ...
Gillian Dao Nyesiga +10 more
doaj +1 more source
Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]
, 2017 It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core
Influence of oxidative stress on aryl hydrocarbon receptor signaling [PDF]
, 2013 The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per- Arnt-Sim) super-family of transcription factors.
Mohammadi Bardbori, Afshin
core +1 more source
Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials
Advanced Materials, EarlyView.A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella +3 more
wiley +1 more source