Results 31 to 40 of about 494,082 (309)
European Journal of Inflammation, 2021 Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system.
Won-Ho Hahn +3 more
doaj +1 more source
Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
core +4 more sources
Th1/Th2 cytokine production and reception features in Graves' disease
Клиническая и экспериментальная тиреоидология, 2012 Cytokines and their receptors belong to a significant role in the initiation and the subsequent course and outcome of autoimmune thyroid disease. Interleukin-2 (IL-2), interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF-α)-cytokines, which have a ...
doaj +1 more source
Педиатрическая фармакология, 2011 Identification of the early markers of the onset of atopic march in children remains important for the effective primary and secondary prevention of allergic diseases.
T.V. Turti +2 more
doaj +2 more sources
Current Therapeutic Research, 2014 Background: Hypertonic saline is often used to resuscitate patients experiencing shock. In such conditions, polymorphonuclear cells and Toll-like receptors (TLRs) form an essential part of early induced innate immunity.
Sung-Hyuk Choi, MD, PhD +5 more
doaj +1 more source
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core +1 more source
Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study [PDF]
Clinical and Molecular Allergy, 2005 Abstract Background IL4/IL4RA pathway plays an important role in atopy and asthma. Different polymorphisms in IL4 and IL4RA genes have been described. Particularly, -33C>TIL4 and 576Q>RIL4RA SNPs have been independently associated to atopy and asthma.
Lorente Félix +5 more
openaire +3 more sources
Molecules, 2016 Toll-like receptors (TLRs) are the most upstream pattern recognition receptors in the cell, which detect pathogen associated molecular patterns and initiate signal transduction, culminating in the transcription of pro-inflammatory cytokines and antiviral
Mahesh Chandra Patra, Sangdun Choi
doaj +1 more source
Novel IL2RG Gene Mutation in One of Dizygotic Twins Causing Profound Changes of Receptor Structure
Frontiers in Pediatrics, 2022 In this study, we report a 4-month-old boy with T−B+NK− severe combined immunodeficiency (SCID) due to a novel mutation in exon 2 of IL2RG, the gene encoding the interleukin (IL) common gamma chain (γc) of the cytokine receptors for IL-2, IL-4, IL-7, IL ...
Magdalena Rutkowska-Zapała +6 more
doaj +1 more source
Association of Severe Respiratory Syncytial Virus Bronchiolitis with Interleukin‐4 and Interleukin‐4 Receptor α Polymorphisms [PDF]
The Journal of Infectious Diseases, 2003 The association of variants of genes encoding interleukin (IL)-4 and the IL-4 receptor alpha chain (IL-4Ralpha) with respiratory syncytial virus (RSV) bronchiolitis was examined in hospitalized infants. Polymorphisms in IL-4 (C-590T) and IL-4Ralpha (I50V and Q551R) were genotyped by restriction fragment-length polymorphism analysis.
Hoebee, B +8 more
openaire +2 more sources