Results 11 to 20 of about 499,428 (289)

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. [PDF]

Proceedings of the National Academy of Sciences, 1995
A detailed structure-function analysis of human interleukin 5 (hIL5) has been performed. The hIL5 receptor is composed of two different polypeptide chains, the alpha and beta subunits. The alpha subunit alone is sufficient for ligand binding, but association with the beta subunit leads to a 2- to 3-fold increase in binding affinity.
J, Tavernier, T, Tuypens, A, Verhee, G, Plaetinck, R, Devos, J, Van der Heyden, Y, Guisez, C, Oefner   +7 more
openaire   +4 more sources

Interleukin-5 and Interleukin-5 Receptor Polymorphism in Asthma

, 2023
Asthma is a common chronic inflammatory disease of the airways of the lungs, in the world. It’s associated with type 2 cytokines interleukin-4, IL-5, and IL-13, which promote airway eosinophilia, bronchial hyperresponsiveness, mucus overproduction, and immunogloubulin E synthesis.
Maytham, Hameed, Raghdah, Najim, Abood, Haidar Abdul Amir, Mohsin, Ahmed, Mohanad   +2 more
openaire   +2 more sources

Receptor Epitope Usage by an Interleukin-5 Mimetic Peptide [PDF]

Journal of Biological Chemistry, 2005
The cyclic peptide AF17121 is a library-derived antagonist for human interleukin-5 (IL5) receptor alpha (IL5Ralpha) and inhibits IL5 activity. Our previous results have demonstrated that the sixth arginine residue of the peptide is crucial for the inhibitory effect and that several acidic residues in the N- and C-terminal regions also make a ...
Tetsuya, Ishino, Cecilia, Urbina, Madhushree, Bhattacharya, Dominick, Panarello, Irwin, Chaiken   +4 more
openaire   +2 more sources

Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines. [PDF]

Proceedings of the National Academy of Sciences, 1989
Interleukin 5 (IL-5) is a glycosylated polypeptide that acts as a key factor for B-cell growth and differentiation. We demonstrated previously that there are two classes (high and low affinity) of IL-5 receptors on murine chronic B-cell leukemic cells (BCL1-B20).
S, Mita, A, Tominaga, Y, Hitoshi, K, Sakamoto, T, Honjo, M, Akagi, Y, Kikuchi, N, Yamaguchi, K, Takatsu   +8 more
openaire   +2 more sources

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains [PDF]

Proceedings of the National Academy of Sciences, 2000
Two series of peptides that specifically bind to the extracellular domain of the α chain of the human interleukin-5 receptor (IL-5Rα), but share no primary sequence homology to IL-5, were identified from libraries of random recombinant peptides. Affinity maturation procedures generated a 19-aa peptide that binds to the IL-5 receptor α/β heterodimer ...
B P, England, P, Balasubramanian, I, Uings, S, Bethell, M J, Chen, P J, Schatz, Q, Yin, Y F, Chen, E A, Whitehorn, A, Tsavaler, C L, Martens, R W, Barrett, M, McKinnon   +12 more
openaire   +2 more sources

A computational analysis of transcriptional profiles from CD8(+) T lymphocytes reveals potential mechanisms of HIV/AIDS control and progression

Computational and Structural Biotechnology Journal, 2021
Cytotoxic and noncytotoxic CD8+ T lymphocyte responses are essential for the control of HIV infection. Understanding the mechanisms underlying HIV control in elite controllers (ECs), which maintain undetectable viral load in the absence of antiretroviral
Sergey Ivanov, Dmitry Filimonov, Olga Tarasova   +2 more
doaj   +1 more source

Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children

Frontiers in Immunology, 2018
Lower respiratory tract infections (LRTI) are often caused by Streptococcus pneumoniae (Spn) and can be recurrent in 8% of children older than 2 years of age.
Johan N. Siebert, Johan N. Siebert, Lutz Hamann, Charlotte M. Verolet, Cécile Gameiro, Stéphane Grillet, Claire-Anne Siegrist, Claire-Anne Siegrist, Claire-Anne Siegrist, Klara M. Posfay-Barbe, Klara M. Posfay-Barbe   +10 more
doaj   +1 more source

Nicotinamide inhibits melanoma in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2020
Background Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the amide form of Niacin, was ...
Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano, Antonio Facchiano   +8 more
doaj   +1 more source

Novel Biological Therapies for Severe Asthma Endotypes

Biomedicines, 2022
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini, Alessandro Vatrella   +8 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources