Results 71 to 80 of about 18,523 (160)
Frontiers in Immunology, 2017 Cancer is still one of the world’s most pressing health-care challenges, leading to a high number of deaths worldwide. Immunotherapy is a new developing therapy that boosts patient’s immune system to fight cancer by modifying tumor–immune cells ...
Paola de Andrade Mello +2 more
doaj +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.Hydrogel microspheres (HMs) enhance the properties of traditional hydrogels, offering better injectability and functionality. Advanced fabrication techniques enable precise control over their size and properties. Stimuli‐responsive HMs, which react to pH, ROS, and enzymes, allow targeted drug release and tissue repair.
Jiacheng Liu +11 more
wiley +1 more source
Expression and distribution of ectonucleotidases in mouse urinary bladder.
PLoS ONE, 2011 BackgroundNormal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling is ATP.
Weiqun Yu, Simon C Robson, Warren G Hill
doaj +1 more source
The role of purinergic receptors in stem cell differentiation
Computational and Structural Biotechnology Journal, 2015 A major challenge modern society has to face is the increasing need for tissue regeneration due to degenerative diseases or tumors, but also accidents or warlike conflicts.
Constanze Kaebisch +3 more
doaj +1 more source
Purinergic signaling and cholangiocyte regeneration: a new frontier in ischemic liver injury
Frontiers in TransplantationCholangiocytes—the epithelial cells lining the biliary tree—are especially vulnerable to ischemic injury, particularly in the setting of orthotopic liver transplantation (OLT). This susceptibility stems from their reliance on an arterial blood supply and
Chinedu Nwaduru +7 more
doaj +1 more source
Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
Frontiers in Pharmacology, 2018 Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+) are released as danger signals from cells during infection and sterile inflammation.
Stephan Menzel +3 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential ...
Zhichao Zhou +13 more
doaj +1 more source
Adenosine: Direct and Indirect Actions on Gastric Acid Secretion
Frontiers in Physiology, 2017 Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts.
Rosa M. Arin +5 more
doaj +1 more source
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Purinergic Signalling Purinergic Signalling, 2023 Seyed Hossein Kiaie +6 more
semanticscholar +1 more source