Results 71 to 80 of about 7,951 (196)

Purinergic Signalling and Neurological Diseases: An Update [PDF]

, 2017
Purinergic signalling, i.e. ATP as an extracellular signalling molecule and cotransmitter in both peripheral and central neurons, is involved in the physiology of neurotransmission and neuromodulation.
Burnstock, G
core   +1 more source

Modulators of Ion Transport in Nasal Polyps: An Measurement of Short-Circuit Current [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesTo examine possible modulators of the ion transport through the apical membrane of the nasal polyps.MethodsThe study was conducted using the freshly-excised nasal polyps from the patients with chronic sinusitis.
Jun Ho Lee, Chae-Seo Rhee, Dae Woo Kim, Chul Hee Lee   +3 more
doaj   +1 more source

Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy

European Journal of Immunology, Volume 54, Issue 12, December 2024.
The absence of adenosine receptor A2B on myeloid cells in Adora2B923f/f‐LysMCre mice resulted in systemic changes in myeloid and lymphoid cell populations during pregnancy. There was an increased expression of IL‐6 and a reduction of MDSC and uNK cells. However, there were only marginal differences in pregnancy outcomes.
Stefanie Dietz, Janine Hebel, Jessica Rühle, Alisha Huff, Holger K. Eltzschig, Trim Lajqi, Christian F. Poets, Christian Gille, Natascha Köstlin‐Gille   +8 more
wiley   +1 more source

NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]

PLoS ONE, 2013
Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi, Hirokazu Arai, Toshihiko Momiyama   +2 more
doaj   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

Research progress of microglial surface receptors in perioperative neurocognitive disorders

Ibrain, Volume 10, Issue 4, Page 450-461, Winter 2024.
Perioperative factors such as surgical trauma, anesthetic, and inflammatory factors act on microglia in the brain. The receptor on microglia is activated to promote or inhibit the occurrence of inflammatory reactions, which, in turn, induce or prevent the occurrence of perioperative neurocognitive disorder (PND).
Chun‐Chun Tang, De‐Xing Liu, Zhao‐Qiong Zhu   +2 more
wiley   +1 more source

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

P2X7 expression patterns in the developing Fmr1‐knockout mouse hippocampus

Hippocampus, Volume 34, Issue 11, Page 633-644, November 2024.
Abstract Fragile‐X Syndrome (FXS) is the leading monogenetic cause of intellectual disability among children but remains without a cure. Using the Fmr1 KO mouse model of FXS, much work has been done to understand FXS hippocampus dysfunction. Purinergic signaling, where ATP and its metabolites are used as signaling molecules, participates in hippocampus
Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L. Scott   +4 more
wiley   +1 more source

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Frontiers in Cellular Neuroscience, 2019
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk   +13 more
doaj   +1 more source

Short- and long-term (trophic) purinergic signalling [PDF]

, 2016
There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body, in addition to fast purinergic signalling in neurotransmission ...
Burnstock, G
core   +1 more source