Results 81 to 90 of about 7,951 (196)

Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function

The Journal of Physiology, Volume 602, Issue 21, Page 5659-5684, 1 November 2024.
Abstract figure legend We determined how physiological extremes of O2 and CO2 impact redox regulation of cerebral bioenergetic function. World‐class breath‐hold divers performed two maximal apnoeas resulting in hypoxaemic hypercapnia (prior normoxic normoventilation) and hyperoxaemic hypercapnia (prior hyperoxic hyperventilation).
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Benjamin S. Stacey, Angelo Iannetelli, Gareth W. Davison, Rasmus H. Dahl, Ronan M. G. Berg, David B. MacLeod, Zeljko Dujic, Philip N. Ainslie   +12 more
wiley   +1 more source

Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

Frontiers in Immunology, 2017
Cancer is still one of the world’s most pressing health-care challenges, leading to a high number of deaths worldwide. Immunotherapy is a new developing therapy that boosts patient’s immune system to fight cancer by modifying tumor–immune cells ...
Paola de Andrade Mello, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +2 more
doaj   +1 more source

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Advanced Science, Volume 11, Issue 39, October 23, 2024.
Craniopharyngioma (CP) is an intracranial tumor with prevalent hypothalamic comorbidities. The roles of gut microbiome and serum metabolome in CP‐associated hypothalamic comorbidities are aimed to be explored. The potential of increased Clostridium is demonstrated and purine metabolism is up‐regulated as signatures of CP‐associated hypothalamic ...
Ben Lin, Zhen Ye, Zhan Cao, Zhao Ye, Yifei Yu, Weiliang Jiang, Sichen Guo, Vladimir Melnikov, Peng Zhou, Chenxing Ji, Chengzhang Shi, Zerui Wu, Zhengyuan Chen, Yihua Xu, Qilin Zhang, Zengyi Ma, Nidan Qiao, Long Chen, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Li Zhang, Min He, Yongfei Wang, Hongying Ye, Yiming Li, Zhaoyun Zhang, Meng Wang, Renyuan Gao, Yichao Zhang   +29 more
wiley   +1 more source

Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement [PDF]

, 2017
We previously demonstrated that uridine adenosine tetraphosphate (Up4A) induces potent and partially endothelium-dependent relaxation in the healthy porcine coronary microvasculature.
Beer, V.J. (Vincent Jacob) de, Cheng, C. (Caroline), Danser, A.H.J. (Jan), Duncker, D.J.G.M. (Dirk), Heinonen, I.H.A. (Ilkka), Merkus, D. (Daphne), Sorop, O. (Oana), Zhou, Z. (Zhichao)   +7 more
core   +2 more sources

Connexin 30 locally controls actin cytoskeleton and mechanical remodeling in motile astrocytes

Glia, Volume 72, Issue 10, Page 1915-1929, October 2024.
Main Points Astroglial Cx30 interacts with the actin cytoskeleton and impairs its local remodeling during migration This alters the local membrane physical surface and migrating properties of motile astrocytes. Abstract During brain maturation, astrocytes establish complex morphologies unveiling intense structural plasticity.
Grégory Ghézali, Jérôme Ribot, Nathan Curry, Laure‐Elise Pillet, Flora Boutet‐Porretta, Daria Mozheiko, Charles‐Félix Calvo, Pascal Ezan, Isabelle Perfettini, Laure Lecoin, Sébastien Janel, Jonathan Zapata, Carole Escartin, Sandrine Etienne‐Manneville, Clemens F. Kaminski, Nathalie Rouach   +15 more
wiley   +1 more source

The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity

Advanced Science, Volume 11, Issue 36, September 25, 2024.
This study reveals the critical involvement of the SWELL1 channel in ischemic brain injury pathogenesis, highlighting its role in cytotoxic neuronal swelling and astrocytic glutamate excitotoxicity. Notably, pharmacological inhibition of SWELL1 by the FDA‐approved drug Dicumarol effectively blocks these deleterious pathways, underscoring SWELL1 as a ...
Jianan Chen, Junhua Yang, Jiachen Chu, Kevin Hong Chen, Jesse Alt, Rana Rais, Zhaozhu Qiu   +6 more
wiley   +1 more source

Extracellular ATP and its derivatives provide spatiotemporal guidance for bone adaptation to wide spectrum of physical forces

Bone Reports, 2022
ATP is a ubiquitous intracellular molecule critical for cellular bioenergetics. ATP is released in response to mechanical stimulation through vesicular release, small tears in cellular plasma membranes, or when cells are destroyed by traumatic forces ...
Chrisanne Dsouza, Mahmoud S. Moussa, Nicholas Mikolajewicz, Svetlana V. Komarova   +3 more
doaj  

Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer\u27s disease [PDF]

, 2020
A promising new therapeutic target for the treatment of Alzheimer\u27s disease (AD) is the circadian system. Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in ...
Griffin, Percy, Kim, Do Eon, Kim, Dong-Hou, Lee, Jiyeon, Musiek, Erik S, Sheehan, Patrick W, Yoon, Seung-Yong   +6 more
core   +1 more source

Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus [PDF]

, 2007
Adenosine and ATP, via their specific P1 and P2 receptors, modulate a wide variety of cellular and tissue functions, playing a neuroprotective or neurodegenerative role in brain damage conditions. Although, in general, adenosine inhibits excitability and
Amadio, Anderson, Bachevalier, Benvensiste, Bergersen, Bergersen, Bezzi, Blum, Braun, Burnstock, C. Martini, Chaudhry, Choi, Ciruela, Ciruela, Cordeaux, Cotman, Cunha, Dixon, Duarte, Dunwiddie, Franke, Franke, Franke, Franke, Franke, Fredholm, Fredholm, Fredholm, Fumagalli, Gao, Giuntini, Gottlieb, Gundersen, Gundersen, Gylterud Owe, Hagberg, Harry, Hoffmann, Hollopeter, Hourani, I. Tonazzini, J. Storm-Mathisen, Jimenez, Jourdain, Kawamura, Koizumi, L. H. Bergersen, Lasley, Lopes, Lorenzen, Lorenzen, M. L. Trincavelli, Maemoto, Masino, Mendoza-Fernandez, Moore, Moore, Moran-Jimenez, Moro, Munshi, Murphy, Nagelhus, Nakata, Neary, Newman, Niebauer, Ochiishi, Ottersen, Palmer, Piper, Ponzio, Rathbone, Rebola, Rebola, Rodrigues, Rudolphi, Sasaki, Swanson, Trincavelli, Vohringer, Volonté, Von Kugelgen, Waldo, Wang, Wang, Wardas, Yoshioka, Yoshioka, Yoshioka, Zhang, Zhu, Zimmermann   +92 more
core   +2 more sources

Molecular regulation of calcium‐sensing receptor (CaSR)‐mediated signaling

Chronic Diseases and Translational Medicine, Volume 10, Issue 3, Page 167-194, September 2024.
The CaSR interactome characterizes the life cycle of CaSR and its signaling capacity. (1) Extracellular calcium activates CaSR and (2) mediates intracellular G‐protein‐coupled signaling, leading to ER calcium release by generating IP3 through phospholipase C (PLC) hydrolysis of PIP2.
Li Tian, Corey Andrews, Qiuyun Yan, Jenny J. Yang   +3 more
wiley   +1 more source