Results 91 to 100 of about 28,974 (217)

Possible neuroprotective role of P2X2 in the retina of diabetic rats

Diabetology & Metabolic Syndrome, 2018
Background Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is
Jorge E. Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P. Salica, Emiliano S. Lopez, J. Oscar Croxatto, Juan E. Gallo   +6 more
doaj   +1 more source

P2 Purinergic Signaling in the Distal Lung in Health and Disease

International Journal of Molecular Sciences, 2020
The distal lung provides an intricate structure for gas exchange in mammalian lungs. Efficient gas exchange depends on the functional integrity of lung alveoli.
E. Wirsching, M. Fauler, G. Fois, M. Frick   +3 more
semanticscholar   +1 more source

Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]

, 2009
Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke, Glorieux, Griet, Jankowski, Joachim, Jankowski, Vera, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This review systematically presents an updated and comprehensive overview of transfusion‐related acute lung injury (TRALI), a serious complication of blood transfusions. It explores TRALI's clinical features, potential causes, and immune mechanisms. Key insights include the roles of signaling pathways and possible therapies, with a focus on prevention ...
Xiaobin Fang, Chunheng Mo, Ling Zheng, Fei Gao, Fu‐Shan Xue, Xiaochun Zheng   +5 more
wiley   +1 more source

Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury

Cell Transplantation, 2015
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D., Francisco Javier Rodríguez-Jiménez, Ana Alastrue-Agudo, Miodrag Stojkovic, María Teresa Miras-Portugal, Victoria Moreno-Manzano   +5 more
doaj   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

British Journal of Pharmacology, Volume 182, Issue 6, Page 1324-1340, March 2025.
Background and Purpose Abdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated in the pathogenesis of abdominal pain, the relative paucity of TRPV4 expression in colon‐projecting sensory neurons suggests that non‐neuronal
Michelle Y. Meng, Luke W. Paine, David Sagnat, Ivana Bello, Sophie Oldroyd, Farideh Javid, Matthew T. Harper, James R. F. Hockley, Ewan St. John Smith, Róisín M. Owens, Laurent Alric, Etienne Buscail, Fraser Welsh, Nathalie Vergnolle, David C. Bulmer   +14 more
wiley   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Mechanisms of comorbidity between Alzheimer's disease and pain

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management.
Kaifang Yao, Shenjun Wang, Zhifang Xu, Zezhi Fan, Zhihan Chen, Peng Jia, Shiwei Tu, Yangyang Liu, Xiaowei Lin, Yuan Xu, Yuxing Fang, Baomin Dou, Yi Guo   +12 more
wiley   +1 more source

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +1 more source