Results 21 to 30 of about 28,974 (217)
Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]
Journal of Innate ImmunityBackground: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde +6 more
doaj +2 more sources
Purinergic signalling: past, present and future [PDF]
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
Burnstock, G
core +3 more sources
Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia [PDF]
Journal of Neuroinflammation, 2009 Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Crain, Jessica M +2 more
core +5 more sources
P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction
Frontiers in Pharmacology, 2020 Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla +15 more
doaj +2 more sources
Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin [PDF]
PathogensClostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo +14 more
doaj +2 more sources
Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus
International Journal of Molecular Sciences, 2021 ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological ...
J. Lommen +4 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2022 Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore,
Nour Mesto +2 more
doaj +1 more source
Purinergic signaling: Diverse effects and therapeutic potential in cancer
Frontiers in Oncology, 2023 Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
doaj +1 more source
Purinergic Signaling in Spermatogenesis
Frontiers in Endocrinology, 2022 Adenosine triphosphate (ATP) serves as the essential source of cellular energy. Over the last two decades, however, ATP has also attracted increasing interest as an extracellular signal that activates purinergic plasma membrane receptors of the P2 family.
Nadine Mundt +5 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall +5 more
doaj +1 more source