Results 191 to 200 of about 2,306,220 (297)

Identifying Suitable Reference Gene Candidates for Quantification of DNA Damage-Induced Cellular Responses in Human U2OS Cell Culture System. [PDF]

Biomolecules, 2023
Barta N, Ördög N, Pantazi V, Berzsenyi I, Borsos BN, Majoros H, Páhi ZG, Ujfaludi Z, Pankotai T.   +8 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

qPCR-Based Reference Gene Validation in <i>Canarium album</i>: Stability Across Varieties and Developmental Stages. [PDF]

Curr Issues Mol Biol
Zhao Q, Jiang L, Luo W, Wang W, Shen C, Ye Q, Chen Q, Xie Q.   +7 more
europepmc   +1 more source

Identification of RNU44 as an Endogenous Reference Gene for Normalizing Cell-Free RNA in Tuberculosis. [PDF]

Open Forum Infect Dis, 2022
Gu W, Tu X, Lu W, Yin Y, Meng Q, Wang X, Zhang F, Fu Y.   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluation of Suitable Reference Gene During the Development of Paired or Unpaired Female <i>Schistosoma japonicum</i> on the 18th and the 23rd Days Post Infection. [PDF]

Pathogens
Wang S, Feng L, Sun J.
europepmc   +1 more source

Reference Gene Selection for qPCR Analysis in Schima superba under Abiotic Stress. [PDF]

Genes (Basel), 2022
Yao J, Zhu G, Liang D, He B, Wang Y, Cai Y, Zhang Q.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Identification of SnRNA U6 as an endogenous reference gene for normalization of MiRNA expression data in COVID-19 patients. [PDF]

Sci Rep
de Santana Silva ÍTS, Fehlberg HF, Ferreira FB, da Silva MF, Dos Santos PR, Porto VM, Dias JCT, Albuquerque GR, Mariano APM, Gadelha SR, Kaneto CM.   +10 more
europepmc   +1 more source

Validation of reference gene stability for miRNA quantification by reverse transcription quantitative PCR in the peripheral blood of patients with COVID-19 critical illness. [PDF]

PLoS One, 2023
Formosa A, Acton E, Lee A, Turgeon P, Izhar S, Plant P, Tsoporis JN, Soussi S, Trahtemberg U, Baker A, Dos Santos CC.   +10 more
europepmc   +1 more source