Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy [PDF]
Radiation Oncology, 2019 Background Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated tumors like heavier ions, while ...
Stewart Mein +12 more
doaj +6 more sources
Relative Biological Effectiveness (RBE) of 131I Radiation Relative to 60Co Gamma Rays [PDF]
Cell Journal, 2013 Objective: To assess relative biological effectiveness (RBE) of 131I radiation relative to 60Co gamma rays in glioblastoma spheroid cells.Materials and Methods: In this experimental study, glioblastoma spheroid cells were exposed to 131I radiation and ...
Seyed Rabie Mahdavi +2 more
doaj +3 more sources
Proton relative biological effectiveness (RBE): a multiscale problem. [PDF]
Br J Radiol, 2019 Proton radiotherapy is undergoing rapid expansion both within the UK and internationally, but significant challenges still need to be overcome if maximum benefit is to be realised from this technique. One major limitation is the persistent uncertainty in proton relative biological effectiveness (RBE).
Underwood TS, McMahon SJ.
europepmc +6 more sources
Evaluation of organ-specific relative biological effectiveness of proton therapy using radiation-induced pneumonitis as an endpoint [PDF]
Clinical and Translational Radiation OncologyBackground and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy’s ...
Li Liao +9 more
doaj +2 more sources
Applied SciencesA constant proton relative biological effectiveness (RBE) of 1.1 for tumor control is currently used in proton therapy treatment planning. However, in vitro, in vivo and clinical experiences indicate that proton RBE varies with kinetic energy and ...
Dimitris Dalalas +5 more
doaj +3 more sources
Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations [PDF]
EJNMMI PhysicsBackground 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE).
Ziyi Hu +9 more
doaj +2 more sources
Variable Relative Biological Effectiveness of Protons in the Rat Spinal Cord: Measurements and Comparison With Model Calculations [PDF]
Advances in Radiation OncologyPurpose: To determine the relative biological effectiveness (RBE) in the rat spinal cord after 6 fractions of protons as a function of linear energy transfer (LET) and dose.
Christin Glowa, PhD +11 more
doaj +2 more sources
The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy
Advances in Radiation Oncology, 2021 Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological damage of protons.
Helge Henjum, MSc +7 more
doaj +1 more source
A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE)
Radiotherapy and Oncology, 2022 Recently, a number of clinical studies have explored links between possible Relative Biological Effectiveness (RBE) elevations and patient toxicities and/or image changes following proton therapy. Our objective was to perform a systematic review of such studies.
Underwood, T. +5 more
openaire +3 more sources
An ion-independent phenomenological relative biological effectiveness (RBE) model for proton therapy
Radiotherapy and Oncology, 2022 27 pages, 10 figures (4 in the supplementary)
Tian, Liheng +2 more
openaire +3 more sources