Results 21 to 30 of about 9,817 (201)

Establishment of a new three-dimensional dose evaluation method considering variable relative biological effectiveness and dose fractionation in proton therapy combined with high-dose-rate brachytherapy

Journal of Medical Physics, 2019
Purpose: The purpose of this study is to evaluate the influence of variable relative biological effectiveness (RBE) of proton beam and dose fractionation has on dose distribution and to establish a new three-dimensional dose evaluation method for proton ...
Daisuke Kobayashi, Tomonori Isobe, Kenta Takada, Yutaro Mori, Hideyuki Takei, Hiroaki Kumada, Satoshi Kamizawa, Tetsuya Tomita, Eisuke Sato, Hiroshi Yokota, Takeji Sakae   +10 more
doaj   +1 more source

Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Michael Scholz, Thomas Friedrich, Giulio Magrin, Paolo Colautti, Aleksandra Ristić-Fira, Ivan Petrović   +5 more
doaj   +1 more source

Calibration and evaluation of the relative biological effectiveness for carbon-ion radiotherapy in a new relative to a clinically applied treatment planning system

Radiation Oncology, 2022
Background The study objective was to validate the relative biological effectiveness (RBE) in RayStation for carbon-ion radiotherapy (CIRT) using the Syngo treatment planning system as reference. Methods Local effect model I was established in RayStation
Weiwei Wang, Zhijie Huang, Wei Sun, Xufei Wang, Jingfang Zhao, Hao Shen   +5 more
doaj   +1 more source

Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo [PDF]

Acta Oncologica, 2017
The aim of the present study was to examine the RBE for early damage in an in vivo mouse model, and the effect of the increased linear energy transfer (LET) towards the distal edge of the spread-out Bragg peak (SOBP).The lower part of the right hind limb of CDF1 mice was irradiated with single fractions of either 6 MV photons, 240 kV photons or ...
Sørensen, Brita Singers, Bassler, Niels, Nielsen, Steffen, Horsman, Michael R, Grzanka, Leszek, Spejlborg, Harald, Swakoń, Jan, Olko, Paweł, Overgaard, Jens   +8 more
openaire   +2 more sources

Biological Dose Estimation Model for Proton Beam Therapy [PDF]

, 2015
Purpose: The recommended value for the relative biological effectiveness (RBE) of proton beams is currently assumed to be 1.1. However, there is increasing evidence that RBE increases towards the end of proton beam range that may increase the biological ...
Anferov, Vladimir, Das, Indra J.
core   +1 more source

Efficient rejoining of DNA double-strand breaks despite increased cell-killing effectiveness following spread-out Bragg peak carbon-ion irradiation

Frontiers in Oncology, 2016
Radiotherapy of solid tumors with charged particles holds several advantages in comparison to photon therapy; among them conformal dose distribution in the tumor, improved sparing of tumor-surrounding healthy tissue, and an increased relative biological ...
Nicole Bernadette Averbeck, Jana eTopsch, Jana eTopsch, Michael eScholz, Wilma eKraft-Weyrather, Marco eDurante, Marco eDurante, Gisela eTaucher-Scholz, Gisela eTaucher-Scholz   +8 more
doaj   +1 more source

Limitations in Predicting the Space Radiation Health Risk for Exploration Astronauts [PDF]

, 2018
Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews ...
Auñón-Chancellor, Serena M., Blue, Rebecca S., Cengel, Keith A., Chancellor, Jeffery C., Katzgraber, Helmut G., Kennedy, Ann R., Rubins, Kathleen H.   +6 more
core   +4 more sources

Sensitivity analysis of Monte Carlo model of a gantry-mounted passively scattered proton system [PDF]

, 2020
PURPOSE: This study aimed to present guidance on the correlation between treatment nozzle and proton source parameters, and dose distribution of a passive double scattering compact proton therapy unit, known as Mevion S250.
Baradaran-Ghahfarokhi, Milad, Prusator, Michael T, Reynoso, Francisco, Sun, Baozhou, Zhao, Tianyu   +4 more
core   +2 more sources

Microdosimetric analysis confirms similar biological effectiveness of external exposure to gamma-rays and internal exposure to 137Cs, 134Cs, and 131I. [PDF]

PLoS ONE, 2014
The risk of internal exposure to 137Cs, 134Cs, and 131I is of great public concern after the accident at the Fukushima-Daiichi nuclear power plant. The relative biological effectiveness (RBE, defined herein as effectiveness of internal exposure relative ...
Tatsuhiko Sato, Kentaro Manabe, Nobuyuki Hamada   +2 more
doaj   +1 more source

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source