Results 111 to 120 of about 25,961 (244)

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, Volume 13, Issue 34, 19 June 2026.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

ETV4 Improves Cerebral Ischemia‐Reperfusion Injury by Restraining YBX1‐GPX4‐Ferroptosis Cascades

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Qian Xu, Faming Deng, Dan Yu
wiley   +1 more source

Imperatorin ameliorates myocardial ischemia‐reperfusion injury by inhibiting endoplasmic reticulum stress‐mediated apoptosis via the PI3K/AKT/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
By activating the PI3K/AKT/Nrf2 pathway, imperatorin can reduce endoplasmic reticulum stress and its mediated apoptosis in cardiomyocytes, improve the pathological changes of myocardial tissue, and thus improve myocardial ischemia/reperfusion injury.
Mingjun Han, Fan Yu, Huanhuan Li
wiley   +1 more source

The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer

Frontiers in Oncology, 2019
Hans Crezee, H. P. Kok, Arlene L. Oei, Arlene L. Oei, Arlene L. Oei, Nicolaas A. P. Franken, Nicolaas A. P. Franken, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Lukas J. A. Stalpers, Lukas J. A. Stalpers   +10 more
doaj   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury

Journal of Inflammation Research
Haihong Deng,1,* Qisen Fan,2,* Lichao Huang,1 Wenbo Ouyang,1 Wendian Zhu3 1Department of Anesthesiology, The First People’s Hospital of Zhaoqing, Zhaoqing City, Guangdong Province, People’s Republic of China; 2Department of Anesthesiology, The ...
Deng H, Fan Q, Huang L, Ouyang W, Zhu W
doaj  

USP5‐C‐MAF Axis Regulates Autophagy‐Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng, Kai Wu, Yinjun Huang, Lei Cao, Huichao Fu   +4 more
wiley   +1 more source

Influence of reoxygenation at different temperatures on growth, hematological and oxidative stress parameters in Piaractus mesopotamicus. [PDF]

Fish Physiol Biochem
Lamberti LG, Nitz LF, Presa LS, Pellegrin L, Bitencourt AL, Garcia L.   +5 more
europepmc   +1 more source