Results 21 to 30 of about 10,096 (216)

A combination treatment of low-dose dexamethasone and aspirin-triggered resolvin D1 reduces Sjögren syndrome–like features in a mouse modelWhy Is This Important?

JADA Foundational Science, 2023
Background: Sjögren syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and diminished secretory function of the salivary glands. Dexamethasone (DEX) resolves dry mouth and lymphocytic infiltration; however, this treatment is
Harim Tavares dos Santos, DDS, PhD, Frank Maslow, BS, Kihoon Nam, PhD, Bryan Trump, DDS, Gary A. Weisman, PhD, Olga J. Baker, DDS, PhD   +5 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Differential effects of resolvin D1 and resolvin E1 on cementoblast function

Journal of Periodontology, 2023
AbstractBackgroundResolvins are endogenous mediators of the resolution of inflammation. They are derived from omega‐3 polyunsaturated fatty acid precursors. Resolvin D1 (RvD1) and Resolvin E1 (RvE1) are the best‐characterized members for actively promoting periodontal regeneration in experimental animal models.
Bozkurt, Serife Buket, Hakki, Sema Sezgin, Kantarci, Alpdogan   +2 more
openaire   +2 more sources

Resolvins and inflammatory pain [PDF]

F1000 Medicine Reports, 2011
Resolvins are a group of molecules derived from omega-3 fatty acids. They are part of a biochemical program that allows inflamed tissues to return to homeostasis once the need for the inflammatory response is over. Resolvins act in very low dose ranges in vitro and in vivo.
Sommer, Claudia, Birklein, Frank
openaire   +2 more sources

The Impact of the Ca²⁺-Independent Phospholipase A₂β (iPLA₂β) on Immune Cells

Biomolecules, 2021
The Ca2+-independent phospholipase A2β (iPLA2β) is a member of the PLA2 family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and ...
Tayleur D. White, Abdulaziz Almutairi, Ying Gai Tusing, Xiaoyong Lei, Sasanka Ramanadham   +4 more
doaj   +1 more source

Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies

Cureus, 2022
This systematic review aimed to assess scientific data of existing literature to identify the efficacy of resolvins (Rv) in the treatment of periodontitis.
Nouf Alshibani
semanticscholar   +1 more source

Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2 [PDF]

Infection and Immunity, 2018
ABSTRACT Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD). CD is a persistent, lifelong infection affecting many organs, most notably the heart, where it may result in acute myocarditis and chronic cardiomyopathy. The pathological features include myocardial inflammation and fibrosis.
Romain A. Colas, Anthony W. Ashton, Shankar Mukherjee, Jesmond Dalli, Oscar B. Akide-Ndunge, Huan Huang, Mahalia S. Desruisseaux, Fangxia Guan, Linda A. Jelicks, Fabiane Matos dos Santos, Jyothi Nagajyothi, Michael A. Zingman, Jinet Reyes, Louis M. Weiss, Charles N. Serhan, Herbert B. Tanowitz   +15 more
openaire   +3 more sources

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

Frontiers in Immunology, 2020
Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19).
Anandita Pal, Kymberly M. Gowdy, Kenneth J. Oestreich, Melinda Beck, Saame Raza Shaikh   +4 more
doaj   +1 more source

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5^−/− Mice

Metabolites, 2021
Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating ...
Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H. Weylandt, Lothar H. Wieler, Dagmar Heydeck, Hartmut Kuhn   +13 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source