Results 11 to 20 of about 8,166 (214)
The Journal of Experimental Medicine, 2002 Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators. Here, we report that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid (DHA) (C22:6) produce a novel
Serhan, Charles N. +6 more
openaire +3 more sources
Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
Mediators of Inflammation, 2020 Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 ...
Sajad Chamani +6 more
doaj +3 more sources
Formation of lipoxins and resolvins in human leukocytes
Prostaglandins & Other Lipid Mediators, 2023 Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- or 15-lipoxygenases using arachidonic acid, eicosapentaenoic acid or docosahexaenoic acid as substrate.
Kahnt, Astrid Stefanie +2 more
openaire +4 more sources
Frontiers in Immunology, 2020 Resolvins, the member of specialized pro-resolving mediators, are produced from omega-3 polyunsaturated fatty acids as a response to an acute inflammatory process in that termination and resolution of inflammation.
Aslıhan Avanoǧlu Güler +8 more
doaj +3 more sources
Resolvins as Regulators of the Immune System [PDF]
The Scientific World JOURNAL, 2010 Inflammation is the first response of the immune system to infection or injury, but excessive or inappropriate inflammatory responses contribute to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of ω-3 polyunsaturated fatty acids (i.e., eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) indicate ...
Hiroyuki Seki +3 more
openaire +5 more sources
Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?
Drug Design, Development and Therapy, 2016 Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid ...
Hesselink JMK, Chiosi F, Costagliola C
doaj +1 more source
Resolution of depression: Antidepressant actions of resolvins
Neuroscience ResearchMajor depressive disorder, one of the most widespread mental illnesses, brings about enormous individual and socioeconomic consequences. Conventional monoaminergic antidepressants require weeks to months to produce a therapeutic response, and approximately one-third of the patients fail to respond to these drugs and are considered treatment-resistant ...
Satoshi Deyama +2 more
openaire +4 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Differential effects of resolvin D1 and resolvin E1 on cementoblast function
Journal of Periodontology, 2023 AbstractBackgroundResolvins are endogenous mediators of the resolution of inflammation. They are derived from omega‐3 polyunsaturated fatty acid precursors. Resolvin D1 (RvD1) and Resolvin E1 (RvE1) are the best‐characterized members for actively promoting periodontal regeneration in experimental animal models.
Bozkurt, Serife Buket +2 more
openaire +2 more sources
The Emerging Roles of Resolvins: Potential Diagnostic Biomarkers for Cardiovascular Diseases [PDF]
Current Cardiology ReviewsBurak Yazgan
exaly +2 more sources