Results 31 to 40 of about 7,733 (208)
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Archives of Medical Science, 2021 COVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system.
Undurti N. Das
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Resolvins: Potent Pain Inhibiting Lipid Mediators via Transient Receptor Potential Regulation
Frontiers in Cell and Developmental Biology, 2020 Chronic pain is a serious condition that occurs in the peripheral nervous system (PNS) and the central nervous system (CNS). It is caused by inflammation or nerve damage that induces the release of inflammatory mediators from immune cells and/or protein ...
Jueun Roh +4 more
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Современная ревматология, 2016 Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
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Resolvins on the way to resolution [PDF]
Journal of Experimental Medicine, 2015 ![Figure][1] Insight from Peter Ward Over the past several decades, lipid products have been found to exert both proinflammatory effects (e.g., prostaglandins and leukotrienes) and antiinflammatory activities (e.g., lipoxins and products derived from docosahexaenoic acid ...
openaire +2 more sources
Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat [PDF]
The Journal of Immunology, 2012 Abstract The unprecedented increase in the prevalence of obesity and obesity-related disorders is causally linked to a chronic state of low-grade inflammation in adipose tissue. Timely resolution of inflammation and return of this tissue to homeostasis are key to reducing obesity-induced metabolic dysfunctions.
Joan, Clària +4 more
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Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents
Chemistry & Biology, 2013 Resolvins are a family of n-3 lipid mediators initially identified in resolving inflammatory exudates that temper inflammatory responses to promote catabasis. Here, temporal metabololipidomics with self-limited resolving exudates revealed that resolvin (Rv) D3 has a distinct time frame from other lipid mediators, appearing late in the resolution phase.
Dalli, Jesmond +7 more
openaire +2 more sources
Metabolites, 2021 Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating ...
Eugenia Marbach-Breitrück +13 more
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Stereoselective syntheses and biological activities of E-series resolvins
, 2021 Recent research efforts focusing on the many mechanisms participating in the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators. These endogenous molecules include the lipoxins, resolvins, protectins and maresins,
Vik, Anders, Hansen, Trond Vidar
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Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?
Frontiers in Endocrinology, 2017 Inflammation, decreased levels of circulating endothelial nitric oxide (eNO) and brain-derived neurotrophic factor (BDNF), altered activity of hypothalamic neurotransmitters (including serotonin and vagal tone) and gut hormones, increased concentrations ...
Undurti N. Das, Undurti N. Das
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The therapeutic potential of resolvins in pulmonary diseases [PDF]
, 2023 Uncontrolled inflammation leads to nonspecific destruction and remodeling of tissues and can contribute to many human pathologies, including pulmonary diseases.
Henricks, Paul A J +2 more
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