Results 31 to 40 of about 10,096 (216)

Resolving Resolvins

open access: yesChemistry & Biology, 2013
In this issue of Chemistry & Biology, Dalli and colleagues report the chemical structures of resolvin D3 (RvD3) and aspirin-triggered RvD3, derived from the ω3-fatty acid docosahexaenoic acid. These compounds have a specific temporal appearance within inflammation resolution and display anti-inflammatory and proresolving properties.
Haeggström, Jesper Z., Hamberg, Mats
openaire   +2 more sources

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia [PDF]

open access: yesThe American Journal of Pathology, 2016
Acute lung injury is a life-threatening condition caused by disruption of the alveolar-capillary barrier leading to edema, influx of inflammatory leukocytes, and impaired gas exchange. Specialized proresolving mediators biosynthesized from essential fatty acids, such as docosahexaenoic acid, have tissue protective effects in acute inflammation. Herein,
Jennifer K, Colby   +13 more
openaire   +2 more sources

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

open access: yesAntioxidants, 2020
Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis.
Gyeoung Jin Kang   +2 more
doaj   +1 more source

Infection, Inflammation, and Immunity in Sepsis

open access: yesBiomolecules, 2023
Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or RNA of the invading organisms or damaged nuclear material (in the form of ...
Undurti N. Das
doaj   +1 more source

Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?

open access: yesLipids in Health and Disease, 2008
Dyslipidemia, and inflammatory markers: high-sensitivity C-reactive protein (hs-CRP), myeloperoxidase (MPO), lipoprotein associated phospholipase A2(Lp-PLA2), and lipid peroxides (LP) are insufficient to predict the onset, extent, and prognosis of CHD ...
Das Undurti N
doaj   +1 more source

Restoration of Proresolution Pathway with Exogenous Resolvin D1 Prevents Sevoflurane-Induced Cognitive Decline by Attenuating Neuroinflammation in the Hippocampus in Rats with Type 2 Diabetes Mellitus

open access: yesFrontiers in Pharmacology, 2021
Sevoflurane (SEV), a commonly used volatile anesthetic, has been shown to cause cognitive decline in diabetic rats by aggregating neuroinflammation in the hippocampus, but the underlying mechanisms are unknown.
Qingmei Sun   +6 more
doaj   +1 more source

Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

open access: yesGut, 2020
Objective Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation.
E. Perna   +13 more
semanticscholar   +1 more source

Resolvins as potential candidates for the treatment of major depressive disorder.

open access: yesJournal of Pharmacological Sciences, 2021
In contrast with the delayed onset of therapeutic responses and relatively low efficacy of currently available monoamine-based antidepressants, a single subanesthetic dose of ketamine, an N-methyl-D-aspartate receptor antagonist, produces rapid and ...
Satoshi Deyama, M. Minami, K. Kaneda
semanticscholar   +1 more source

EICOSANOIDS AND INFLAMMATION

open access: yesСовременная ревматология, 2016
Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj   +1 more source

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

open access: yesMolecules, 2022
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente   +4 more
doaj   +1 more source

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