Results 51 to 60 of about 7,733 (208)

Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Metabolites
Acute inflammation is the body’s first defense in response to pathogens or injury that is partially governed by a novel genus of endogenous lipid mediators that orchestrate the resolution of inflammation, coined specialized pro-resolving mediators (SPMs).
Muhammad Usman Babar, Ala F. Nassar, Xinxin Nie, Tianxiang Zhang, Jianwei He, Jacky Yeung, Paul Norris, Hideki Ogura, Anne Muldoon, Lieping Chen, Stephania Libreros   +10 more
doaj   +1 more source

Inflammatory and Pro-resolving Lipids in Trypanosomatid Infections: A Key to Understanding Parasite Control

Frontiers in Microbiology, 2018
Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp.) are protozoan parasites that cause neglected diseases affecting millions of people in Africa, Asia, and the Americas.
Rodrigo A. López-Muñoz, Alfredo Molina-Berríos, Carolina Campos-Estrada, Carolina Campos-Estrada, Patricio Abarca-Sanhueza, Luis Urrutia-Llancaqueo, Miguel Peña-Espinoza, Juan D. Maya   +7 more
doaj   +1 more source

Resolvin D1 and Resolvin D5 Lower Antibiotic Doses in Infection

The FASEB Journal, 2013
Underlying mechanisms for how bacterial infections contribute to active resolution of acute inflammation are unknown. Here, we carried out LM‐metabololipidomics following Escherichia coli (E. coli) infections in mice for temporal identification of pro‐inflammatory (prostaglandins and ...
Nan Chiang, Gabrielle Fredman, Sungwhan Oh, Charles N Serhan   +3 more
openaire   +1 more source

Comparison of effectiveness of low-dose aspirin versus omega-3 fatty acids as adjuvants to nonsurgical periodontal therapy in Type II diabetic patients with chronic periodontitis

Journal of Indian Society of Periodontology, 2019
Context: Periodontitis and diabetes are universally prevalent diseases which are interlinked with each other. Inflammatory products released both by the microorganisms, and the host plays a pivotal role in causing both the diseases.
Prathyusha Rampally, Rekha Rani Koduganti, Sastri Nadiminty Ganapathi, Veerendranath Reddy Panthula, Prasanna Jammula Surya   +4 more
doaj   +1 more source

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications

Frontiers in Pharmacology, 2018
Diabetes and its associated chronic complications present a healthcare challenge on a global scale. Despite improvements in the management of chronic complications of the micro-/macro-vasculature, their growing prevalence and incidence highlights the ...
Monica de Gaetano, Caitriona McEvoy, Caitriona McEvoy, Darrell Andrews, Antonino Cacace, Jonathan Hunter, Eoin Brennan, Catherine Godson   +7 more
doaj   +1 more source

Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome

Frontiers in Immunology, 2023
Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren’s syndrome, the causes of the disease are as yet ...
Harim T. dos Santos, Harim T. dos Santos, Kihoon Nam, Kihoon Nam, Diana Gil, Diana Gil, Diana Gil, Venkata Yellepeddi, Venkata Yellepeddi, Olga J. Baker, Olga J. Baker, Olga J. Baker   +11 more
doaj   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation[S]

Journal of Lipid Research, 2014
Resolution of inflammation is an active process involving specialized proresolving mediators (SPM) formed from the n-3 fatty acids. This study examined the effect of n-3 fatty acid supplementation and aspirin on plasma SPMs in healthy humans.
Anne Barden, Emilie Mas, Kevin D. Croft, Michael Phillips, Trevor A. Mori   +4 more
doaj   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

Peri‐implant disease pathogenesis animal models: Consensus report of Workgroup 1 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis, Leonardo Mancini, Panos Afouxenides, Andrea Roccuzzo, IADR IRG Peri‐implantitis Best Evidence Consensus Working Group 1, Tara Aghaloo, Georgios Belibasakis, Nagihan Bostanci, Li Dehua, Nikolaos Donos, Alpdogan Kantarci, Alireza Moshaverinia, Flavia Pirih, Mia Rakic, Frank Schwarz, Sukirth Ganesan   +15 more
wiley   +1 more source