Results 51 to 60 of about 8,166 (214)
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.A recombinant whole‐cell platform expressing a bacterial 15S‐LOX exhibiting 5S‐LOX activity enabled the stereoselective production of RvE2 and 17R‐RvD5 from 18R‐HEPE and 17R‐HDHA, achieving final concentrations of 0.57 mM and 1.48 mM from 4.0 mM substrates, respectively, under optimized conditions.
Hee‐Gyeong Lee +2 more
wiley +1 more source
Frontiers in Immunology, 2020 G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion, and inflammation. However, the function of this receptor in human neutrophils, one of the first leukocytes to arrive at the site of ...
Patricia R. Souza +8 more
doaj +1 more source
The effect of osteoblast addition to critical defect and the effect of D4 and D5 resolvins to calvaria [PDF]
, 2021 OBJECTIVE: A calvarial defect model was used to study the effect of additions of osteoblasts in both a grid culture and implantation onto chick embryo membrane.
Shah, Nischit
core +1 more source
TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley +1 more source
Resolvins and protectins: mediating solutions to inflammation [PDF]
British Journal of Pharmacology, 2009 Resolution of inflammation has historically been viewed as a passive process, occurring as a result of the withdrawal of pro‐inflammatory signals, including lipid mediators such as leukotrienes and prostaglandins. Thus, most anti‐inflammatory drugs have traditionally targeted primarily mediator pathways that are engaged at the onset of inflammation ...
Payal, Kohli, Bruce D, Levy
openaire +2 more sources
Back to the Eosinophil: Resolvin Spatiotemporal Regulation
American Journal of Respiratory Cell and Molecular Biology, 2023 Eosinophils are granulocytes that home to sites of infection and injury, where they can initiate and drive host defense and allergic inflammatory responses. Eosinophil accumulation at different mucosal sites, including the lung and gastrointestinal tract, is also strongly linked with disease pathogenesis (1–3).
Donovan, Chantal +2 more
openaire +2 more sources
Journal of Periodontology, EarlyView.Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis +15 more
wiley +1 more source
Molecules, 2021 Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria.
Julianne M. Thornton, Kingsley Yin
doaj +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose Anterior cruciate ligament (ACL) injuries are increasing in children and adolescents and reconstruction (ACLR) is now frequently performed in this population. Paediatric patients remain at higher risk of reinjury, possibly due to delayed graft remodelling.
Caroline de Pesters +7 more
wiley +1 more source