Results 81 to 90 of about 54,681 (257)

Alkylphosphocholines Inhibit Proliferation of Human Retinal Pigment Epithelial Cells

Investigative Opthalmology & Visual Science, 2003
PURPOSE: To investigate the effect and mechanism of action of alkylphosphocholines (APCs) on proliferation of human retinal pigment epithelium (RPE) cells and RPE-mediated collagen matrix contraction in vitro. METHODS: Cultured RPE cells of five human donors were treated with four APCs in the presence of fetal calf serum.
Kirsten H, Eibl, Bernhard, Banas, Carlo-L, Schoenfeld, Christian A, May, Aljoscha S, Neubauer, Siegfried, Priglinger, Anselm, Kampik, Ulrich, Welge-Lussen   +7 more
openaire   +2 more sources

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells

Nature Communications, 2020
Whilst pigmentation has been used to identify retinal pigment epithelial (RPE) cells, surface markers for these cells remain unclear. Here, the authors define surface markers for the RPE including CD140b, which help produce hPSC-derived RPE cells at a ...
Alvaro Plaza Reyes, Sandra Petrus-Reurer, Sara Padrell Sánchez, Pankaj Kumar, Iyadh Douagi, Hammurabi Bartuma, Monica Aronsson, Sofie Westman, Emma Lardner, Helder André, Anna Falk, Emeline F. Nandrot, Anders Kvanta, Fredrik Lanner   +13 more
doaj   +1 more source

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

A novel AhR ligand, 2AI, protects the retina from environmental stress. [PDF]

, 2016
Various retinal degenerative diseases including dry and neovascular age-related macular degeneration (AMD), retinitis pigmentosa, and diabetic retinopathy are associated with the degeneration of the retinal pigmented epithelial (RPE) layer of the retina.
Davis, Sonnet S, Garcia, Thelma Y, Gutierrez, Mark A, Hubbard, Troy D, Lamba, Deepak A, Mateen, Samiha, Mitchell, Kylie P, Mooney, Shaun, Neves, Joana, Nguyen, Steven M, Perdew, Gary H, Ramanathan, Arvind, Rosko, Andrew   +12 more
core   +2 more sources

Cytokine Production by Retinal Pigmented Epithelial Cells

, 1993
Publisher Summary This chapter discusses cytokine production by retinal pigmented epithelial cells. The retinal pigmented epithelium (RPE) has many functions through which it assists the photoreceptors in visual transduction. In addition to the well-recognized day-to-day maintenance functions, the RPE also plays a very active role in normal and ...
openaire   +2 more sources

Understanding the spacing of placodes in the eye: A comparative study across age and species

The Anatomical Record, EarlyView.
Abstract The conjunctival placodes of the avian eye form in an intriguing and conserved sequence in a circular annulus around the cornea. These 13–16 placodes develop into papillae that are essential for inducing underlying intramembranous flat bones, known as scleral ossicles, which form an important part of the ocular skeleton.
Florence Joseph, Tamara A. Franz‐Odendaal   +1 more
wiley   +1 more source

Inflammatory factors secreted from endothelial cells induced by high glucose impair human retinal pigment epithelial cells

Türk Biyokimya Dergisi
Diabetic retinopathy (DR) is a retinal disease that arises from impaired glucose tolerance and leads to retinal microvascular leakages. Recent studies have indicated that DR pathogenesis is linked to dysfunctional retinal pigment epithelial (RPE) cells.
Yao Hui, Li Tingjun, Zhang Jing
doaj   +1 more source

Structure and function of the retinal pigment epithelium, photoreceptors and cornea in the eye of Sardinella aurita (Clupeidae, Teleostei)

Journal of Basic and Applied Zoology, 2016
The structure of the pigment epithelium, photoreceptors and the cornea in the eye of a teleost, Sardinella aurita was examined by light and electron microscopy.
Mostafa Ali Salem
doaj   +1 more source

Scrambled Eggs: Apoptotic cell clearance by non-professional phagocytes in the Drosophila ovary [PDF]

, 2017
This manuscript was supported by NIH grant R01 GM060574 to KM.
McCall, Kimberly, Serizier, Sandy B.
core   +1 more source