Results 31 to 40 of about 121,393 (276)
Neural Regeneration Research, 2019 All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways ...
Bhaskar C Das +2 more
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Alternative retinoid X receptor (RXR) ligands
Molecular and Cellular Endocrinology, 2019 Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization with other nuclear hormone receptors (NRs), contributing thereby to activities of different signaling pathways. We review known RXR ligands as transcriptional modulators of specific RXR-dimers and the associated biological processes.
Wojciech Krężel +2 more
openaire +3 more sources
Effects of PPARγ Ligands on Leukemia
PPAR Research, 2012 Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
Yoko Tabe +3 more
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Canadian Journal of Gastroenterology, 2003 The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
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Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids.
Chemical and Pharmaceutical Bulletin, 1999 Several dibenzodiazepine derivatives were identified as novel retinoid X receptor (RXR) antagonists on the basis of inhibitory activity on retinoid-induced cell differentiation of human promyelocytic leukemia cells HL-60 and transactivation assay using retinoic acid receptors (RARs) and RXRs in COS-1 cells.
M, Ebisawa +10 more
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Journal of Biological Chemistry, 1995 Thyroid hormone (T3) plays a causative role in amphibian metamorphosis. This regulation is thought to be mediated by heterodimers of T3 receptors (TRs) and retinoid X receptors (RXRs).
J. Wong, Yunbo Shi
semanticscholar +1 more source
9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. [PDF]
PLoS Genetics, 2015 The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of (patho)-physiological processes. Although synthetic RXR ligands are developed for
Ralph Rühl +11 more
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Phytanic Acid is a Retinoid X Receptor Ligand [PDF]
European Journal of Biochemistry, 1996 Metabolic defects in phytanic acid catabolism have been shown to be connected with a number of human diseases which can lead to lethal defects of the nervous system and other organs. These effects are probably a result of the very high accumulation of phytanic acid in tissues throughout the body, due to defects in phytanic acid oxidation, the ...
P K, Lemotte, S, Keidel, C M, Apfel
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Journal of Biological Chemistry, 1995 Two retinoic acid (RA) receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs), have been identified. All-trans-RA and its 9-cis-isomer are ligands for RARs, but only 9-cis-RA binds RXRs with high affinity.
Yili Yang +4 more
semanticscholar +1 more source
Bioinorganic Chemistry and Applications, 2017 We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors.
Yulia N. Nosova +12 more
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