Results 31 to 40 of about 122,450 (299)
Adaptive evolution of the Retinoid X receptor in vertebrates
Genomics, 2012 Retinoid X receptors (RXR) are transcription factors with important roles in development, reproduction, homeostasis, and cell differentiation. Different types of vertebrate RXRs (α (RXRA), ß (RXRB) and γ (RXRG)) have arisen from multiple duplication events.
Miguel M. Santos +6 more
openaire +3 more sources
Effects of PPARγ Ligands on Leukemia
PPAR Research, 2012 Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
Yoko Tabe +3 more
doaj +1 more source
Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.
Proceedings of the National Academy of Sciences of the United States of America, 1995 We report that methoprene and its derivatives can stimulate gene transcription in vertebrates by acting through the retinoic acid-responsive transcription factors, the retinoid X receptors (RXRs).
M. A. Harmon +3 more
semanticscholar +1 more source
Canadian Journal of Gastroenterology, 2003 The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2004 Microbe-macrophage interactions play a central role in the pathogenesis of many infections. The ability of some bacterial pathogens to induce macrophage apoptosis has been suggested to contribute to their ability to elude innate immune responses and ...
A. Valledor +5 more
semanticscholar +1 more source
9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. [PDF]
PLoS Genetics, 2015 The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of (patho)-physiological processes. Although synthetic RXR ligands are developed for
Ralph Rühl +11 more
doaj +1 more source
The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor [PDF]
The Journal of Physical Chemistry B, 2016 The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization and (anti)cooperative binding of cognate ligands. Here, the structural basis of the positive allostery of RXR and constitutive androstane receptor (CAR) is revealed. In contrast,
Richard J. Lindsay +7 more
openaire +3 more sources
Retinoid X receptors are essential for early mouse development and placentogenesis.
Proceedings of the National Academy of Sciences of the United States of America, 1999 Embryos carrying null mutations of both retinoid X receptors alpha and beta (RXRalpha-/-/RXRbeta-/- mutants) were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormalities.
O. Wendling, P. Chambon, M. Mark
semanticscholar +1 more source
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function [PDF]
Proceedings of the National Academy of Sciences, 2007 Retinoid X receptors (RXRα, -β, and -γ) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)physiologic processes.
Nahoum, Virginie +11 more
openaire +5 more sources
Bioinorganic Chemistry and Applications, 2017 We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors.
Yulia N. Nosova +12 more
doaj +1 more source